The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018
Abstract Background To explore the relationship between blood manganese and liver stiffness in the United States among participants with chronic obstructive pulmonary disease (COPD). Methods All data were obtained from the 2017–2018 National Health and Nutrition Examination Survey database (NHANES)....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00977-5 |
| _version_ | 1797958724699029504 |
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| author | Kexing Han Jiapei Shen Kexuan Tan Jiaying Liu Weijie Sun Yufeng Gao |
| author_facet | Kexing Han Jiapei Shen Kexuan Tan Jiaying Liu Weijie Sun Yufeng Gao |
| author_sort | Kexing Han |
| collection | DOAJ |
| description | Abstract Background To explore the relationship between blood manganese and liver stiffness in the United States among participants with chronic obstructive pulmonary disease (COPD). Methods All data were obtained from the 2017–2018 National Health and Nutrition Examination Survey database (NHANES). A total of 4690 participants were included in the study. All participants included complete information on COPD, liver stiffness, and blood manganese. Liver stiffness (kPa) was measured from “Examination Date” and blood manganese (ug/L) was obtained from “Laboratory Data”. A multiple linear regression model was used to assess the correlation between blood manganese and liver stiffness. Results Among the 4690 participants, blood manganese was lower in the COPD group but liver stiffness was higher (p < 0.05). There was a positive correlation between blood manganese and liver stiffness (β = 0.08, 95% CI 0.03, 0.12). This positive association was more pronounced in COPD participants (β = 0.25, 95% CI 0.08, 0.42) and there was a non-linear relationship, which was more significant when blood manganese exceeded 14.43 ug/L (β = 1.76, 95% CI 1.10, 2.41). Conclusions The association between blood manganese and liver stiffness was positive, which was more apparent in COPD patients. |
| first_indexed | 2024-04-11T00:24:07Z |
| format | Article |
| id | doaj.art-84d436b8479545a3a156b1f80f6beb1d |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-11T00:24:07Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-84d436b8479545a3a156b1f80f6beb1d2023-01-08T12:07:51ZengBMCEuropean Journal of Medical Research2047-783X2023-01-0128111010.1186/s40001-022-00977-5The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018Kexing Han0Jiapei Shen1Kexuan Tan2Jiaying Liu3Weijie Sun4Yufeng Gao5Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical UniversityAbstract Background To explore the relationship between blood manganese and liver stiffness in the United States among participants with chronic obstructive pulmonary disease (COPD). Methods All data were obtained from the 2017–2018 National Health and Nutrition Examination Survey database (NHANES). A total of 4690 participants were included in the study. All participants included complete information on COPD, liver stiffness, and blood manganese. Liver stiffness (kPa) was measured from “Examination Date” and blood manganese (ug/L) was obtained from “Laboratory Data”. A multiple linear regression model was used to assess the correlation between blood manganese and liver stiffness. Results Among the 4690 participants, blood manganese was lower in the COPD group but liver stiffness was higher (p < 0.05). There was a positive correlation between blood manganese and liver stiffness (β = 0.08, 95% CI 0.03, 0.12). This positive association was more pronounced in COPD participants (β = 0.25, 95% CI 0.08, 0.42) and there was a non-linear relationship, which was more significant when blood manganese exceeded 14.43 ug/L (β = 1.76, 95% CI 1.10, 2.41). Conclusions The association between blood manganese and liver stiffness was positive, which was more apparent in COPD patients.https://doi.org/10.1186/s40001-022-00977-5Chronic obstructive pulmonary diseaseBlood manganeseLiver stiffnessCross-sectional studyStrengths and limitations of this study |
| spellingShingle | Kexing Han Jiapei Shen Kexuan Tan Jiaying Liu Weijie Sun Yufeng Gao The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018 European Journal of Medical Research Chronic obstructive pulmonary disease Blood manganese Liver stiffness Cross-sectional study Strengths and limitations of this study |
| title | The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018 |
| title_full | The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018 |
| title_fullStr | The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018 |
| title_full_unstemmed | The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018 |
| title_short | The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017–2018 |
| title_sort | association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease a cross sectional study from nhanes 2017 2018 |
| topic | Chronic obstructive pulmonary disease Blood manganese Liver stiffness Cross-sectional study Strengths and limitations of this study |
| url | https://doi.org/10.1186/s40001-022-00977-5 |
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