Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics
Abstract Nanomedicine presents exciting new opportunities for the detection and treatment of cancer. Current cancer imaging methods and treatment approaches in clinics frequently fall short of entirely curing cancer and can have severe side effects. Theranostic nanoparticles, however, have the poten...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-12-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202300462 |
| _version_ | 1797392876299091968 |
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| author | Marijus Pleckaitis Vitalijus Karabanovas Greta Butkiene Jonas Venius Marius Burkanas Giedre Grinciene Arunas Jagminas Ricardas Rotomskis |
| author_facet | Marijus Pleckaitis Vitalijus Karabanovas Greta Butkiene Jonas Venius Marius Burkanas Giedre Grinciene Arunas Jagminas Ricardas Rotomskis |
| author_sort | Marijus Pleckaitis |
| collection | DOAJ |
| description | Abstract Nanomedicine presents exciting new opportunities for the detection and treatment of cancer. Current cancer imaging methods and treatment approaches in clinics frequently fall short of entirely curing cancer and can have severe side effects. Theranostic nanoparticles, however, have the potential to revolutionize effective cancer treatment and early cancer detection. The objective of this study is to show how magnetic iron oxide nanoparticles and photoluminescent gold nanoclusters (MN‐AuNCs) may be combined effectively to produce bimodal imaging nanoparticles that possess magnetic and optical properties and can be used for both magnetic resonance imaging and optical biopsy. These findings demonstrate that MN‐AuNCs, when exposed to visible light, also have the capability to produce singlet oxygen, which is necessary for photodynamic therapy of cancer. In addition, it shows that they are non‐toxic, accumulate inside the cells, and cause cell death during exposure to visible light. The creation of these MN‐AuNCs offers a novel remedy for the current shortcomings in cancer diagnosis and treatment. Since they have both therapeutic and imaging capabilities, MN‐AuNCs have the potential to improve patient outcomes while lowering the risk of negative side effects. |
| first_indexed | 2024-03-08T23:53:51Z |
| format | Article |
| id | doaj.art-84d481d3584a40b092f7fd12faef14fb |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-08T23:53:51Z |
| publishDate | 2023-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-84d481d3584a40b092f7fd12faef14fb2023-12-13T08:17:06ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-12-011035n/an/a10.1002/admi.202300462Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer TheranosticsMarijus Pleckaitis0Vitalijus Karabanovas1Greta Butkiene2Jonas Venius3Marius Burkanas4Giedre Grinciene5Arunas Jagminas6Ricardas Rotomskis7Biomedical Physics Laboratory National Cancer Institute P. Baublio str. 3b Vilnius LT‐08406 LithuaniaDepartment of Chemistry and Bioengineering Vilnius Gediminas Technical University Sauletekio Ave. 11 Vilnius LT‐10223 LithuaniaBiomedical Physics Laboratory National Cancer Institute P. Baublio str. 3b Vilnius LT‐08406 LithuaniaBiomedical Physics Laboratory National Cancer Institute P. Baublio str. 3b Vilnius LT‐08406 LithuaniaMedical Physics Department National Cancer Institute Santariskiu str. 1 Vilnius LT‐08660 LithuaniaState Research Institute Center for Physical Sciences and Technology Sauletekio Ave. 3 Vilnius LT‐10257 LithuaniaState Research Institute Center for Physical Sciences and Technology Sauletekio Ave. 3 Vilnius LT‐10257 LithuaniaBiomedical Physics Laboratory National Cancer Institute P. Baublio str. 3b Vilnius LT‐08406 LithuaniaAbstract Nanomedicine presents exciting new opportunities for the detection and treatment of cancer. Current cancer imaging methods and treatment approaches in clinics frequently fall short of entirely curing cancer and can have severe side effects. Theranostic nanoparticles, however, have the potential to revolutionize effective cancer treatment and early cancer detection. The objective of this study is to show how magnetic iron oxide nanoparticles and photoluminescent gold nanoclusters (MN‐AuNCs) may be combined effectively to produce bimodal imaging nanoparticles that possess magnetic and optical properties and can be used for both magnetic resonance imaging and optical biopsy. These findings demonstrate that MN‐AuNCs, when exposed to visible light, also have the capability to produce singlet oxygen, which is necessary for photodynamic therapy of cancer. In addition, it shows that they are non‐toxic, accumulate inside the cells, and cause cell death during exposure to visible light. The creation of these MN‐AuNCs offers a novel remedy for the current shortcomings in cancer diagnosis and treatment. Since they have both therapeutic and imaging capabilities, MN‐AuNCs have the potential to improve patient outcomes while lowering the risk of negative side effects.https://doi.org/10.1002/admi.202300462cancer theranosticsdual‐imaginggold nanoclustersmagnetic iron oxide nanoparticlesphotodynamic therapy |
| spellingShingle | Marijus Pleckaitis Vitalijus Karabanovas Greta Butkiene Jonas Venius Marius Burkanas Giedre Grinciene Arunas Jagminas Ricardas Rotomskis Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics Advanced Materials Interfaces cancer theranostics dual‐imaging gold nanoclusters magnetic iron oxide nanoparticles photodynamic therapy |
| title | Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics |
| title_full | Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics |
| title_fullStr | Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics |
| title_full_unstemmed | Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics |
| title_short | Magnetic Nanoparticles Decorated with Gold Nanoclusters–Applications in Cancer Theranostics |
| title_sort | magnetic nanoparticles decorated with gold nanoclusters applications in cancer theranostics |
| topic | cancer theranostics dual‐imaging gold nanoclusters magnetic iron oxide nanoparticles photodynamic therapy |
| url | https://doi.org/10.1002/admi.202300462 |
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