Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans.
BACKGROUND: Emerging evidence suggests that microRNAs play a critical role in the pathogenesis of breast cancer. Several molecular epidemiological studies were conducted in recent years to evaluate the association between has-miR-146a rs2910164 polymorphism and breast cancer risk in diverse populati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3282774?pdf=render |
| _version_ | 1811234362678575104 |
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| author | Hai Lian Lei Wang Jingmin Zhang |
| author_facet | Hai Lian Lei Wang Jingmin Zhang |
| author_sort | Hai Lian |
| collection | DOAJ |
| description | BACKGROUND: Emerging evidence suggests that microRNAs play a critical role in the pathogenesis of breast cancer. Several molecular epidemiological studies were conducted in recent years to evaluate the association between has-miR-146a rs2910164 polymorphism and breast cancer risk in diverse populations. However, the results remain conflicting rather than conclusive. METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis of 6 case-control studies that included 4238 breast-cancer cases and 4469 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, this meta-analysis showed that the rs2910164 polymorphism was not associated with a significantly increased risk of breast cancer in all genetic models (for GC vs GG: OR = 1.00, 95% CI = 0.90-1.09, P(heterpgeneity) = 0.364; for CC vs GG: OR = 1.16, 95% CI = 0.98-1.36, P(heterpgeneity) = 0.757; for GC+CC vs GG: OR = 1.02, 95% CI = 0.93-1.12, P(heterpgeneity) = 0.562; for CC vs GC+GG: OR = 1.10, 95% CI = 0.96-1.26, P(heterpgeneity) = 0.441). However, in the stratified analysis by ethnicity, we found the rs2910164 polymorphism was associated with increased breast cancer risk among Europeans in homozygote comparison (CC vs. GG: OR = 1.29, 95%CI = 1.02-1.63, P(heterpgeneity) = 0.950, P = 0.032) and recessive model (CC vs. GC+GG: OR = 1.31, 95%CI = 1.05-1.65, P(heterpgeneity) = 0.839, P = 0.019). No publication bias was found in the present study. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests, for the first time, that the CC homozygote of rs2910164 may contribute to breast cancer susceptibility in Europeans. |
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| id | doaj.art-84d550d45d51440d9e9ab7cd8b821203 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T11:36:28Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-84d550d45d51440d9e9ab7cd8b8212032022-12-22T03:34:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0172e3161510.1371/journal.pone.0031615Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans.Hai LianLei WangJingmin ZhangBACKGROUND: Emerging evidence suggests that microRNAs play a critical role in the pathogenesis of breast cancer. Several molecular epidemiological studies were conducted in recent years to evaluate the association between has-miR-146a rs2910164 polymorphism and breast cancer risk in diverse populations. However, the results remain conflicting rather than conclusive. METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis of 6 case-control studies that included 4238 breast-cancer cases and 4469 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, this meta-analysis showed that the rs2910164 polymorphism was not associated with a significantly increased risk of breast cancer in all genetic models (for GC vs GG: OR = 1.00, 95% CI = 0.90-1.09, P(heterpgeneity) = 0.364; for CC vs GG: OR = 1.16, 95% CI = 0.98-1.36, P(heterpgeneity) = 0.757; for GC+CC vs GG: OR = 1.02, 95% CI = 0.93-1.12, P(heterpgeneity) = 0.562; for CC vs GC+GG: OR = 1.10, 95% CI = 0.96-1.26, P(heterpgeneity) = 0.441). However, in the stratified analysis by ethnicity, we found the rs2910164 polymorphism was associated with increased breast cancer risk among Europeans in homozygote comparison (CC vs. GG: OR = 1.29, 95%CI = 1.02-1.63, P(heterpgeneity) = 0.950, P = 0.032) and recessive model (CC vs. GC+GG: OR = 1.31, 95%CI = 1.05-1.65, P(heterpgeneity) = 0.839, P = 0.019). No publication bias was found in the present study. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests, for the first time, that the CC homozygote of rs2910164 may contribute to breast cancer susceptibility in Europeans.http://europepmc.org/articles/PMC3282774?pdf=render |
| spellingShingle | Hai Lian Lei Wang Jingmin Zhang Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. PLoS ONE |
| title | Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. |
| title_full | Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. |
| title_fullStr | Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. |
| title_full_unstemmed | Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. |
| title_short | Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans. |
| title_sort | increased risk of breast cancer associated with cc genotype of has mir 146a rs2910164 polymorphism in europeans |
| url | http://europepmc.org/articles/PMC3282774?pdf=render |
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