Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia
Introduction. Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson’s disease. The purpose of this study was to develop and internally validate a clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s d...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2022/6915627 |
| _version_ | 1811188153959055360 |
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| author | Yu-Ting Ling Qian-Qian Guo Si-Min Wang Li-Nan Zhang Jin-Hua Chen Yi Liu Ruo-Heng Xuan Bo Qu Li-Ge Liu Zhi-Shuang Wen Jia-Kun Xu Lu-Lu Jiang Wen-Biao Xian Bin Wu Chang-Ming Zhang Ling Chen Jin-Long Liu Nan Jiang |
| author_facet | Yu-Ting Ling Qian-Qian Guo Si-Min Wang Li-Nan Zhang Jin-Hua Chen Yi Liu Ruo-Heng Xuan Bo Qu Li-Ge Liu Zhi-Shuang Wen Jia-Kun Xu Lu-Lu Jiang Wen-Biao Xian Bin Wu Chang-Ming Zhang Ling Chen Jin-Long Liu Nan Jiang |
| author_sort | Yu-Ting Ling |
| collection | DOAJ |
| description | Introduction. Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson’s disease. The purpose of this study was to develop and internally validate a clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease under general anesthesia. Methods. We conducted a retrospective observational cohort study on the data of 240 patients with Parkinson’s disease who underwent deep brain stimulation of the subthalamic nucleus under general anesthesia. Demographic characteristics, clinical evaluation, imaging data, laboratory data, and surgical anesthesia information were collected. Multivariate logistic regression was used to develop the prediction model for postoperative delirium. Results. A total of 159 patients were included in the cohort, of which 38 (23.90%) had postoperative delirium. Smoking (OR 4.51, 95% CI 1.56–13.02, p<0.01) was the most important risk factor; other independent predictors were orthostatic hypotension (OR 3.42, 95% CI 0.90–13.06, p=0.07), inhibitors of type-B monoamine oxidase (OR 3.07, 95% CI 1.17–8.04, p=0.02), preoperative MRI with silent brain ischemia or infarction (OR 2.36, 95% CI 0.90–6.14, p=0.08), Hamilton anxiety scale score (OR 2.12, 95% CI 1.28–3.50, p<0.01), and apolipoprotein E level in plasma (OR 1.48, 95% CI 0.95–2.29, p=0.08). The area under the receiver operating characteristic curve (AUC) was 0.76 (95% CI 0.66–0.86). A nomogram was established and showed good calibration and clinical predictive capacity. After bootstrap for internal verification, the AUC was 0.74 (95% CI 0.66–0.83). Conclusion. This study provides evidence for the independent inducing factors of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease under general anesthesia. By predicting the development of delirium, our model may identify high-risk groups that can benefit from early or preventive intervention. |
| first_indexed | 2024-04-11T14:15:58Z |
| format | Article |
| id | doaj.art-84d598ae4bda4784a17d5ea6555ac025 |
| institution | Directory Open Access Journal |
| issn | 2042-0080 |
| language | English |
| last_indexed | 2024-04-11T14:15:58Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj.art-84d598ae4bda4784a17d5ea6555ac0252022-12-22T04:19:30ZengHindawi LimitedParkinson's Disease2042-00802022-01-01202210.1155/2022/6915627Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General AnesthesiaYu-Ting Ling0Qian-Qian Guo1Si-Min Wang2Li-Nan Zhang3Jin-Hua Chen4Yi Liu5Ruo-Heng Xuan6Bo Qu7Li-Ge Liu8Zhi-Shuang Wen9Jia-Kun Xu10Lu-Lu Jiang11Wen-Biao Xian12Bin Wu13Chang-Ming Zhang14Ling Chen15Jin-Long Liu16Nan Jiang17Department of AnesthesiologyDepartment of AnesthesiologyDepartment of AnesthesiologyDepartment of AnesthesiologyDepartment of NeurologyDepartment of AnesthesiologyDepartment of NeurosurgeryDepartment of AnesthesiologyDepartment of AnesthesiologyDepartment of AnesthesiologyDepartment of NeurosurgeryDepartment of NeurologyDepartment of NeurologyDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurologyDepartment of NeurosurgeryDepartment of AnesthesiologyIntroduction. Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson’s disease. The purpose of this study was to develop and internally validate a clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease under general anesthesia. Methods. We conducted a retrospective observational cohort study on the data of 240 patients with Parkinson’s disease who underwent deep brain stimulation of the subthalamic nucleus under general anesthesia. Demographic characteristics, clinical evaluation, imaging data, laboratory data, and surgical anesthesia information were collected. Multivariate logistic regression was used to develop the prediction model for postoperative delirium. Results. A total of 159 patients were included in the cohort, of which 38 (23.90%) had postoperative delirium. Smoking (OR 4.51, 95% CI 1.56–13.02, p<0.01) was the most important risk factor; other independent predictors were orthostatic hypotension (OR 3.42, 95% CI 0.90–13.06, p=0.07), inhibitors of type-B monoamine oxidase (OR 3.07, 95% CI 1.17–8.04, p=0.02), preoperative MRI with silent brain ischemia or infarction (OR 2.36, 95% CI 0.90–6.14, p=0.08), Hamilton anxiety scale score (OR 2.12, 95% CI 1.28–3.50, p<0.01), and apolipoprotein E level in plasma (OR 1.48, 95% CI 0.95–2.29, p=0.08). The area under the receiver operating characteristic curve (AUC) was 0.76 (95% CI 0.66–0.86). A nomogram was established and showed good calibration and clinical predictive capacity. After bootstrap for internal verification, the AUC was 0.74 (95% CI 0.66–0.83). Conclusion. This study provides evidence for the independent inducing factors of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease under general anesthesia. By predicting the development of delirium, our model may identify high-risk groups that can benefit from early or preventive intervention.http://dx.doi.org/10.1155/2022/6915627 |
| spellingShingle | Yu-Ting Ling Qian-Qian Guo Si-Min Wang Li-Nan Zhang Jin-Hua Chen Yi Liu Ruo-Heng Xuan Bo Qu Li-Ge Liu Zhi-Shuang Wen Jia-Kun Xu Lu-Lu Jiang Wen-Biao Xian Bin Wu Chang-Ming Zhang Ling Chen Jin-Long Liu Nan Jiang Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia Parkinson's Disease |
| title | Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia |
| title_full | Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia |
| title_fullStr | Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia |
| title_full_unstemmed | Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia |
| title_short | Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia |
| title_sort | nomogram for prediction of postoperative delirium after deep brain stimulation of subthalamic nucleus in parkinson s disease under general anesthesia |
| url | http://dx.doi.org/10.1155/2022/6915627 |
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