CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection.
Gamma-herpesvirus infections are regulated by both CD4+ and CD8+ T cells. However clinical disease occurs mainly in CD4+ T cell-deficient hosts. In CD4+ T cell-deficient mice, CD8+ T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-04-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1006311 |
| _version_ | 1818734942208655360 |
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| author | Cindy S E Tan Clara Lawler Philip G Stevenson |
| author_facet | Cindy S E Tan Clara Lawler Philip G Stevenson |
| author_sort | Cindy S E Tan |
| collection | DOAJ |
| description | Gamma-herpesvirus infections are regulated by both CD4+ and CD8+ T cells. However clinical disease occurs mainly in CD4+ T cell-deficient hosts. In CD4+ T cell-deficient mice, CD8+ T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lung infections differ in distribution: most acute infection was epithelial, whereas most chronic infection was in myeloid cells. CD8+ T cells controlled epithelial infection, but CD4+ T cells and IFNγ were required to control myeloid cell infection. Disrupting the MuHV-4 K3, which degrades MHC class I heavy chains, increased viral epitope presentation by infected lung alveolar macrophages and allowed CD8+ T cells to prevent disease. Thus, viral CD8+ T cell evasion led to niche-specific immune control, and an essential role for CD4+ T cells in limiting chronic infection. |
| first_indexed | 2024-12-18T00:13:22Z |
| format | Article |
| id | doaj.art-84d68f4780274df28ee5430b7309490b |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-18T00:13:22Z |
| publishDate | 2017-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-84d68f4780274df28ee5430b7309490b2022-12-21T21:27:36ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742017-04-01134e100631110.1371/journal.ppat.1006311CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection.Cindy S E TanClara LawlerPhilip G StevensonGamma-herpesvirus infections are regulated by both CD4+ and CD8+ T cells. However clinical disease occurs mainly in CD4+ T cell-deficient hosts. In CD4+ T cell-deficient mice, CD8+ T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lung infections differ in distribution: most acute infection was epithelial, whereas most chronic infection was in myeloid cells. CD8+ T cells controlled epithelial infection, but CD4+ T cells and IFNγ were required to control myeloid cell infection. Disrupting the MuHV-4 K3, which degrades MHC class I heavy chains, increased viral epitope presentation by infected lung alveolar macrophages and allowed CD8+ T cells to prevent disease. Thus, viral CD8+ T cell evasion led to niche-specific immune control, and an essential role for CD4+ T cells in limiting chronic infection.https://doi.org/10.1371/journal.ppat.1006311 |
| spellingShingle | Cindy S E Tan Clara Lawler Philip G Stevenson CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. PLoS Pathogens |
| title | CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. |
| title_full | CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. |
| title_fullStr | CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. |
| title_full_unstemmed | CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. |
| title_short | CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. |
| title_sort | cd8 t cell evasion mandates cd4 t cell control of chronic gamma herpesvirus infection |
| url | https://doi.org/10.1371/journal.ppat.1006311 |
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