Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium
Biomedical magnesium is an ideal material for hard tissue repair and replacement. However, its rapid degradation and infection after implantation significantly hindersclinical applications. To overcome these two critical drawbacks, we describe an integrated strategybased on the changes in pH and Mg2...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-08-01
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| Series: | Journal of Magnesium and Alloys |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956722000184 |
| _version_ | 1797660318104551424 |
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| author | JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi ZhenZhen Dong Yan Li CaiQi Wang |
| author_facet | JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi ZhenZhen Dong Yan Li CaiQi Wang |
| author_sort | JianLiang Zhao |
| collection | DOAJ |
| description | Biomedical magnesium is an ideal material for hard tissue repair and replacement. However, its rapid degradation and infection after implantation significantly hindersclinical applications. To overcome these two critical drawbacks, we describe an integrated strategybased on the changes in pH and Mg2+ triggered by magnesiumdegradation. This system can simultaneously offer anticorrosion and antibacterial activity. First, nanoengineered peptide-grafted hyperbranched polymers (NPGHPs) with excellent antibacterial activity were introduced to sodium alginate (SA) to construct a sensitive NPGHPs/SA hydrogel. The swelling degree, responsiveness, and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg2+ with controllable antimicrobial properties. Furthermore, an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition layer. The alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate, thus exhibiting superior corrosion resistance. Antibacterial testing shows that the material can effectively fight against bacteria, while hemolytic and cytotoxicity testing suggest that it is highly biocompatible. Thus, this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium, thereby providing broader prospects for the use of magnesium. |
| first_indexed | 2024-03-11T18:29:03Z |
| format | Article |
| id | doaj.art-84d74f9aef734c71a0276e77cd3cae17 |
| institution | Directory Open Access Journal |
| issn | 2213-9567 |
| language | English |
| last_indexed | 2024-03-11T18:29:03Z |
| publishDate | 2023-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj.art-84d74f9aef734c71a0276e77cd3cae172023-10-13T13:53:51ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672023-08-0111827892800Anticorrosive and antibacterial smart integrated strategy for biomedical magnesiumJianLiang Zhao0HanRui Cui1ZeYu Gao2YanZe Bi3ZhenZhen Dong4Yan Li5CaiQi Wang6School of ChemicalScience, University of Chinese Academy of Sciences, Beijing, 100049, ChinaSchool of ChemicalScience, University of Chinese Academy of Sciences, Beijing, 100049, ChinaSchool of ChemicalScience, University of Chinese Academy of Sciences, Beijing, 100049, ChinaSchool of Materials Science and Engineering, Beihang University, Beijing 100083, ChinaSchool of ChemicalScience, University of Chinese Academy of Sciences, Beijing, 100049, ChinaSchool of Materials Science and Engineering, Beihang University, Beijing 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing 100191, China; Corresponding authors.School of ChemicalScience, University of Chinese Academy of Sciences, Beijing, 100049, China; Corresponding authors.Biomedical magnesium is an ideal material for hard tissue repair and replacement. However, its rapid degradation and infection after implantation significantly hindersclinical applications. To overcome these two critical drawbacks, we describe an integrated strategybased on the changes in pH and Mg2+ triggered by magnesiumdegradation. This system can simultaneously offer anticorrosion and antibacterial activity. First, nanoengineered peptide-grafted hyperbranched polymers (NPGHPs) with excellent antibacterial activity were introduced to sodium alginate (SA) to construct a sensitive NPGHPs/SA hydrogel. The swelling degree, responsiveness, and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg2+ with controllable antimicrobial properties. Furthermore, an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition layer. The alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate, thus exhibiting superior corrosion resistance. Antibacterial testing shows that the material can effectively fight against bacteria, while hemolytic and cytotoxicity testing suggest that it is highly biocompatible. Thus, this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium, thereby providing broader prospects for the use of magnesium.http://www.sciencedirect.com/science/article/pii/S2213956722000184Biomedical magnesiumAnticorrosionAntibacterialIntelligentNanoengineered peptide-grafted hyperbranched polymers |
| spellingShingle | JianLiang Zhao HanRui Cui ZeYu Gao YanZe Bi ZhenZhen Dong Yan Li CaiQi Wang Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium Journal of Magnesium and Alloys Biomedical magnesium Anticorrosion Antibacterial Intelligent Nanoengineered peptide-grafted hyperbranched polymers |
| title | Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium |
| title_full | Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium |
| title_fullStr | Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium |
| title_full_unstemmed | Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium |
| title_short | Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium |
| title_sort | anticorrosive and antibacterial smart integrated strategy for biomedical magnesium |
| topic | Biomedical magnesium Anticorrosion Antibacterial Intelligent Nanoengineered peptide-grafted hyperbranched polymers |
| url | http://www.sciencedirect.com/science/article/pii/S2213956722000184 |
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