Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty
Abstract Background Aseptic loosening is a leading cause of revision following total hip and knee arthroplasty which is caused by chronic inflammation around the prosthesis. Diabetes mellitus causes systemic inflammatory changes which could increase the risk of aseptic loosening. This study investig...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06376-z |
| _version_ | 1827970655257100288 |
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| author | Yi Deng Paul N Smith Rachel W Li |
| author_facet | Yi Deng Paul N Smith Rachel W Li |
| author_sort | Yi Deng |
| collection | DOAJ |
| description | Abstract Background Aseptic loosening is a leading cause of revision following total hip and knee arthroplasty which is caused by chronic inflammation around the prosthesis. Diabetes mellitus causes systemic inflammatory changes which could increase the risk of aseptic loosening. This study investigated the association between diabetes mellitus and aseptic loosening around hip and knee arthroplasty. Methods A case-control study was conducted at a single arthroplasty centre over the seven-year period of January 2015 to December 2021. Cases were defined as any adult patient undergoing revision hip or knee arthroplasty for aseptic loosening. Controls were randomly selected patients undergoing primary total hip or knee arthroplasty during the same period at a 1:4 ratio. Risk factors were compared between the two groups. Results A total of 440 patients were included in our study – 88 in the aseptic loosening group and 352 patients in the control group. The odds of having diabetes mellitus in the aseptic loosening group was 2.78 (95%CI 1.31–5.92, P = 0.01). Other risk factors were not significantly different between the two groups. Conclusions The incidence of diabetes mellitus is significantly greater in patients undergoing revision arthroplasty for aseptic loosening. Further research is required to explore whether this association is indeed causative. |
| first_indexed | 2024-04-09T18:57:11Z |
| format | Article |
| id | doaj.art-84da814ddbf4495ab3135507c0bbe704 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-09T18:57:11Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-84da814ddbf4495ab3135507c0bbe7042023-04-09T11:06:16ZengBMCBMC Musculoskeletal Disorders1471-24742023-04-012411610.1186/s12891-023-06376-zDiabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplastyYi Deng0Paul N Smith1Rachel W Li2Department of Orthopaedic Surgery, Canberra HospitalDepartment of Orthopaedic Surgery, Canberra HospitalTrauma and Orthopaedic Research Unit, Australian National University School of Medicine and PsychologyAbstract Background Aseptic loosening is a leading cause of revision following total hip and knee arthroplasty which is caused by chronic inflammation around the prosthesis. Diabetes mellitus causes systemic inflammatory changes which could increase the risk of aseptic loosening. This study investigated the association between diabetes mellitus and aseptic loosening around hip and knee arthroplasty. Methods A case-control study was conducted at a single arthroplasty centre over the seven-year period of January 2015 to December 2021. Cases were defined as any adult patient undergoing revision hip or knee arthroplasty for aseptic loosening. Controls were randomly selected patients undergoing primary total hip or knee arthroplasty during the same period at a 1:4 ratio. Risk factors were compared between the two groups. Results A total of 440 patients were included in our study – 88 in the aseptic loosening group and 352 patients in the control group. The odds of having diabetes mellitus in the aseptic loosening group was 2.78 (95%CI 1.31–5.92, P = 0.01). Other risk factors were not significantly different between the two groups. Conclusions The incidence of diabetes mellitus is significantly greater in patients undergoing revision arthroplasty for aseptic loosening. Further research is required to explore whether this association is indeed causative.https://doi.org/10.1186/s12891-023-06376-zAseptic looseningDiabetes mellitusArthroplastyOsteolysisInflammation |
| spellingShingle | Yi Deng Paul N Smith Rachel W Li Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty BMC Musculoskeletal Disorders Aseptic loosening Diabetes mellitus Arthroplasty Osteolysis Inflammation |
| title | Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty |
| title_full | Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty |
| title_fullStr | Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty |
| title_full_unstemmed | Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty |
| title_short | Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty |
| title_sort | diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty |
| topic | Aseptic loosening Diabetes mellitus Arthroplasty Osteolysis Inflammation |
| url | https://doi.org/10.1186/s12891-023-06376-z |
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