Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru

Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru

Abstract Objective The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). Results Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consump...

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Bibliographic Details
Main Authors: Miguel Angel Aguilar-Luis, Fernando Palacios-Cuervo, Fátima Espinal-Reyes, Andrea Calderón-Rivera, Saúl Levy-Blitchtein, Carlos Palomares-Reyes, Wilmer Silva-Caso, Victor Zavaleta-Gavidia, Jorge Bazán-Mayra, Angela Cornejo-Tapia, Juana del Valle-Mendoza, Luis J. del Valle
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Research Notes
Subjects:
Helicobacter pylori
PCR
Clarithromycin
Gastric disease
Peptic ulcer disease
Online Access:http://link.springer.com/article/10.1186/s13104-018-3919-z
Description
Summary:Abstract Objective The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). Results Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consumption the most frequent associated factor in patients with positive PCR for H. pylori infection (93.9%). Clarithromycin resistant mutations were found in 79.6% (39/49) of the positive samples for H. pylori. The most frequent mutation was A2142G (46.9%), followed by the double-mutation A2142G–A2143G (28.6%).
ISSN:1756-0500

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