Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
Abstract Objective The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). Results Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consump...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3919-z |
| _version_ | 1819062267932573696 |
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| author | Miguel Angel Aguilar-Luis Fernando Palacios-Cuervo Fátima Espinal-Reyes Andrea Calderón-Rivera Saúl Levy-Blitchtein Carlos Palomares-Reyes Wilmer Silva-Caso Victor Zavaleta-Gavidia Jorge Bazán-Mayra Angela Cornejo-Tapia Juana del Valle-Mendoza Luis J. del Valle |
| author_facet | Miguel Angel Aguilar-Luis Fernando Palacios-Cuervo Fátima Espinal-Reyes Andrea Calderón-Rivera Saúl Levy-Blitchtein Carlos Palomares-Reyes Wilmer Silva-Caso Victor Zavaleta-Gavidia Jorge Bazán-Mayra Angela Cornejo-Tapia Juana del Valle-Mendoza Luis J. del Valle |
| author_sort | Miguel Angel Aguilar-Luis |
| collection | DOAJ |
| description | Abstract Objective The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). Results Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consumption the most frequent associated factor in patients with positive PCR for H. pylori infection (93.9%). Clarithromycin resistant mutations were found in 79.6% (39/49) of the positive samples for H. pylori. The most frequent mutation was A2142G (46.9%), followed by the double-mutation A2142G–A2143G (28.6%). |
| first_indexed | 2024-12-21T14:56:04Z |
| format | Article |
| id | doaj.art-84ddd5ee71fd4ba582f3cd5dfd83390b |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-21T14:56:04Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-84ddd5ee71fd4ba582f3cd5dfd83390b2022-12-21T18:59:45ZengBMCBMC Research Notes1756-05002018-11-011111610.1186/s13104-018-3919-zHighly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-PeruMiguel Angel Aguilar-Luis0Fernando Palacios-Cuervo1Fátima Espinal-Reyes2Andrea Calderón-Rivera3Saúl Levy-Blitchtein4Carlos Palomares-Reyes5Wilmer Silva-Caso6Victor Zavaleta-Gavidia7Jorge Bazán-Mayra8Angela Cornejo-Tapia9Juana del Valle-Mendoza10Luis J. del Valle11School of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasSchool of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasSchool of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasSchool of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasSchool of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasLaboratorio de Biología Molecular, Instituto de Investigación NutricionalSchool of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasDirección Regional de Salud de Cajamarca (DIRESA-Cajamarca)Dirección Regional de Salud de Cajamarca (DIRESA-Cajamarca)School of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasSchool of Medicine, Research and Innovation Center of the Health Sciences Faculty, Universidad Peruana de Ciencias AplicadasBarcelona Research Center for Multiscale Science and Engineering, Departament d’Enginyeria Química, EEBE, Universidad Politecnica de Catalunya (UPC), Barcelona TechAbstract Objective The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). Results Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consumption the most frequent associated factor in patients with positive PCR for H. pylori infection (93.9%). Clarithromycin resistant mutations were found in 79.6% (39/49) of the positive samples for H. pylori. The most frequent mutation was A2142G (46.9%), followed by the double-mutation A2142G–A2143G (28.6%).http://link.springer.com/article/10.1186/s13104-018-3919-zHelicobacter pyloriPCRClarithromycinGastric diseasePeptic ulcer disease |
| spellingShingle | Miguel Angel Aguilar-Luis Fernando Palacios-Cuervo Fátima Espinal-Reyes Andrea Calderón-Rivera Saúl Levy-Blitchtein Carlos Palomares-Reyes Wilmer Silva-Caso Victor Zavaleta-Gavidia Jorge Bazán-Mayra Angela Cornejo-Tapia Juana del Valle-Mendoza Luis J. del Valle Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru BMC Research Notes Helicobacter pylori PCR Clarithromycin Gastric disease Peptic ulcer disease |
| title | Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru |
| title_full | Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru |
| title_fullStr | Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru |
| title_full_unstemmed | Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru |
| title_short | Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru |
| title_sort | highly clarithromycin resistant helicobacter pylori infection in asymptomatic children from a rural community of cajamarca peru |
| topic | Helicobacter pylori PCR Clarithromycin Gastric disease Peptic ulcer disease |
| url | http://link.springer.com/article/10.1186/s13104-018-3919-z |
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