Iohexol plasma clearance simplified by Dried Blood Spot (DBS) sampling to measure renal function in conscious mice

Iohexol plasma clearance simplified by Dried Blood Spot (DBS) sampling to measure renal function in conscious mice

Abstract There is no simple method to measure glomerular filtration rate (GFR) in mice, which limits the use of mice in models of renal diseases. We aimed at simplifying the plasma clearance of iohexol in mice, using dried blood spot (DBS) sampling in order to reduce the amount of blood taken for an...

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Bibliographic Details
Main Authors: Ana Elena Rodríguez-Rodríguez, Sergio Luis-Lima, Javier Donate-Correa, Laura Diaz-Martín, María Rosa Arnau, Alejandro Jiménez-Sosa, Flavio Gaspari, Alberto Ortiz, Esteban Porrini
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83934-2

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