Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications
Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/5/621 |
| _version_ | 1797536188093956096 |
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| author | Paulo R. Souza Ariel C. de Oliveira Bruno H. Vilsinski Matt J. Kipper Alessandro F. Martins |
| author_facet | Paulo R. Souza Ariel C. de Oliveira Bruno H. Vilsinski Matt J. Kipper Alessandro F. Martins |
| author_sort | Paulo R. Souza |
| collection | DOAJ |
| description | Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings. |
| first_indexed | 2024-03-10T11:56:05Z |
| format | Article |
| id | doaj.art-84e057e916ac47328a3469094c3694dd |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T11:56:05Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-84e057e916ac47328a3469094c3694dd2023-11-21T17:19:31ZengMDPI AGPharmaceutics1999-49232021-04-0113562110.3390/pharmaceutics13050621Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical ApplicationsPaulo R. Souza0Ariel C. de Oliveira1Bruno H. Vilsinski2Matt J. Kipper3Alessandro F. Martins4Group of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, BrazilGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, BrazilGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, BrazilDepartment of Chemical and Biological Engineering, Colorado State University (CSU), Fort Collins, CO 80523, USAGroup of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, BrazilPolysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.https://www.mdpi.com/1999-4923/13/5/621growth factorsscaffoldsantimicrobial coatings |
| spellingShingle | Paulo R. Souza Ariel C. de Oliveira Bruno H. Vilsinski Matt J. Kipper Alessandro F. Martins Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications Pharmaceutics growth factors scaffolds antimicrobial coatings |
| title | Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications |
| title_full | Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications |
| title_fullStr | Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications |
| title_full_unstemmed | Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications |
| title_short | Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications |
| title_sort | polysaccharide based materials created by physical processes from preparation to biomedical applications |
| topic | growth factors scaffolds antimicrobial coatings |
| url | https://www.mdpi.com/1999-4923/13/5/621 |
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