Light-Controllable PROTACs for Temporospatial Control of Protein Degradation
PROteolysis-TArgeting Chimeras (PROTACs) is an emerging and promising approach to target intracellular proteins for ubiquitination-mediated degradation, including those so-called undruggable protein targets, such as transcriptional factors and scaffold proteins. To date, plenty of PROTACs have been...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.678077/full |
| _version_ | 1818742983549255680 |
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| author | Jing Liu Yunhua Peng Wenyi Wei |
| author_facet | Jing Liu Yunhua Peng Wenyi Wei |
| author_sort | Jing Liu |
| collection | DOAJ |
| description | PROteolysis-TArgeting Chimeras (PROTACs) is an emerging and promising approach to target intracellular proteins for ubiquitination-mediated degradation, including those so-called undruggable protein targets, such as transcriptional factors and scaffold proteins. To date, plenty of PROTACs have been developed to degrade various disease-relevant proteins, such as estrogen receptor (ER), androgen receptor (AR), RTK, and CDKs. However, the on-target off-tissue and off-target effect is one of the major limitation that prevents the usage of PROTACs in clinic. To this end, we and several other groups have recently developed light-controllable PROTACs, as the representative for the third generation controllable PROTACs, by using either photo-caging or photo-switch approaches. In this review, we summarize the emerging light-controllable PROTACs and the prospective for other potential ways to achieve temporospatial control of PROTACs. |
| first_indexed | 2024-12-18T02:21:11Z |
| format | Article |
| id | doaj.art-84e3097929e34b0a8dd4f6a7889f06dd |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-18T02:21:11Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-84e3097929e34b0a8dd4f6a7889f06dd2022-12-21T21:24:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.678077678077Light-Controllable PROTACs for Temporospatial Control of Protein DegradationJing LiuYunhua PengWenyi WeiPROteolysis-TArgeting Chimeras (PROTACs) is an emerging and promising approach to target intracellular proteins for ubiquitination-mediated degradation, including those so-called undruggable protein targets, such as transcriptional factors and scaffold proteins. To date, plenty of PROTACs have been developed to degrade various disease-relevant proteins, such as estrogen receptor (ER), androgen receptor (AR), RTK, and CDKs. However, the on-target off-tissue and off-target effect is one of the major limitation that prevents the usage of PROTACs in clinic. To this end, we and several other groups have recently developed light-controllable PROTACs, as the representative for the third generation controllable PROTACs, by using either photo-caging or photo-switch approaches. In this review, we summarize the emerging light-controllable PROTACs and the prospective for other potential ways to achieve temporospatial control of PROTACs.https://www.frontiersin.org/articles/10.3389/fcell.2021.678077/fullubiquitinE3 ligasePROTACtumorigenesislight controllable |
| spellingShingle | Jing Liu Yunhua Peng Wenyi Wei Light-Controllable PROTACs for Temporospatial Control of Protein Degradation Frontiers in Cell and Developmental Biology ubiquitin E3 ligase PROTAC tumorigenesis light controllable |
| title | Light-Controllable PROTACs for Temporospatial Control of Protein Degradation |
| title_full | Light-Controllable PROTACs for Temporospatial Control of Protein Degradation |
| title_fullStr | Light-Controllable PROTACs for Temporospatial Control of Protein Degradation |
| title_full_unstemmed | Light-Controllable PROTACs for Temporospatial Control of Protein Degradation |
| title_short | Light-Controllable PROTACs for Temporospatial Control of Protein Degradation |
| title_sort | light controllable protacs for temporospatial control of protein degradation |
| topic | ubiquitin E3 ligase PROTAC tumorigenesis light controllable |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.678077/full |
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