Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study
Habitual physical activity can diminish the risk of premature death. Identifying a pattern of metabolites related to physical activity may advance our understanding of disease etiology. We quantified 245 serum metabolites in 3802 participants from the Atherosclerosis Risk in Communities (ARIC) study...
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MDPI AG
2021-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/1/59 |
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| author | Jun Xu Guning Liu Sheila M. Hegde Priya Palta Eric Boerwinkle Kelley P. Gabriel Bing Yu |
| author_facet | Jun Xu Guning Liu Sheila M. Hegde Priya Palta Eric Boerwinkle Kelley P. Gabriel Bing Yu |
| author_sort | Jun Xu |
| collection | DOAJ |
| description | Habitual physical activity can diminish the risk of premature death. Identifying a pattern of metabolites related to physical activity may advance our understanding of disease etiology. We quantified 245 serum metabolites in 3802 participants from the Atherosclerosis Risk in Communities (ARIC) study using chromatography–mass spectrometry. We regressed self-reported moderate-to-vigorous intensity leisure-time physical activity (LTPA) against each metabolite, adjusting for traditional risk factors. A standardized metabolite risk score (MRS) was constructed to examine its association with all-cause mortality using the Cox proportional hazard model. We identified 10 metabolites associated with LTPA (<i>p</i> < 2.04 × 10<sup>−4</sup>) and established that an increase of one unit of the metabolic equivalent of task-hours per week (MET·hr·wk<sup>−1</sup>) in LTPA was associated with a 0.012 SD increase in MRS. During a median of 27.5 years of follow-up, we observed 1928 deaths. One SD increase of MRS was associated with a 10% lower risk of death (HR = 0.90, 95% CI: 0.85–0.95). The highest vs. the lowest MRS quintile rank was associated with a 22% reduced risk of death (HR = 0.78, 95% CI: 0.62–0.94). The effects were consistent across race and sex groups. In summary, we identified a set of metabolites associated with LTPA and an MRS associated with a lower risk of death. Our study provides novel insights into the potential mechanisms underlying the health impacts of physical activity. |
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| id | doaj.art-84e43c416e274b59a2da3c6a1500e8f8 |
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| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T04:19:08Z |
| publishDate | 2021-01-01 |
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| series | Metabolites |
| spelling | doaj.art-84e43c416e274b59a2da3c6a1500e8f82023-12-03T13:49:31ZengMDPI AGMetabolites2218-19892021-01-011115910.3390/metabo11010059Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) StudyJun Xu0Guning Liu1Sheila M. Hegde2Priya Palta3Eric Boerwinkle4Kelley P. Gabriel5Bing Yu6Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USADivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USADivision of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Epidemiology, School of Public Health, The University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USAHabitual physical activity can diminish the risk of premature death. Identifying a pattern of metabolites related to physical activity may advance our understanding of disease etiology. We quantified 245 serum metabolites in 3802 participants from the Atherosclerosis Risk in Communities (ARIC) study using chromatography–mass spectrometry. We regressed self-reported moderate-to-vigorous intensity leisure-time physical activity (LTPA) against each metabolite, adjusting for traditional risk factors. A standardized metabolite risk score (MRS) was constructed to examine its association with all-cause mortality using the Cox proportional hazard model. We identified 10 metabolites associated with LTPA (<i>p</i> < 2.04 × 10<sup>−4</sup>) and established that an increase of one unit of the metabolic equivalent of task-hours per week (MET·hr·wk<sup>−1</sup>) in LTPA was associated with a 0.012 SD increase in MRS. During a median of 27.5 years of follow-up, we observed 1928 deaths. One SD increase of MRS was associated with a 10% lower risk of death (HR = 0.90, 95% CI: 0.85–0.95). The highest vs. the lowest MRS quintile rank was associated with a 22% reduced risk of death (HR = 0.78, 95% CI: 0.62–0.94). The effects were consistent across race and sex groups. In summary, we identified a set of metabolites associated with LTPA and an MRS associated with a lower risk of death. Our study provides novel insights into the potential mechanisms underlying the health impacts of physical activity.https://www.mdpi.com/2218-1989/11/1/59metabolomicsphysical activitymortalitymetabolite risk score |
| spellingShingle | Jun Xu Guning Liu Sheila M. Hegde Priya Palta Eric Boerwinkle Kelley P. Gabriel Bing Yu Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study Metabolites metabolomics physical activity mortality metabolite risk score |
| title | Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study |
| title_full | Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study |
| title_fullStr | Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study |
| title_full_unstemmed | Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study |
| title_short | Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study |
| title_sort | physical activity related metabolites are associated with mortality findings from the atherosclerosis risk in communities aric study |
| topic | metabolomics physical activity mortality metabolite risk score |
| url | https://www.mdpi.com/2218-1989/11/1/59 |
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