Uterine myoma. Non-surgical treatment
<b>Uterine myoma. Non-surgical treatment </b><br> Dobrokhotova Yu.E., Ilyina I.Yu., Goncharov I.Yu.<br> <br> Pirogov Russian National Research Medical University, Moscow<br> <br> Uterine myoma occupies one of the leading positions in the struct...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LCC «Medicine-Inform»
2018-02-01
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| Series: | РМЖ. Мать и дитя |
| Online Access: | http://wchjournal.com/upload/iblock/d6d/d6da1eaac870e03be0b537857186915b.pdf |
| _version_ | 1797294969674792960 |
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| author | Yu.E. Dobrokhotova Ilina I.Yu. Goncharov I.Yu. |
| author_facet | Yu.E. Dobrokhotova Ilina I.Yu. Goncharov I.Yu. |
| author_sort | Yu.E. Dobrokhotova |
| collection | DOAJ |
| description | <b>Uterine myoma. Non-surgical treatment </b><br>
Dobrokhotova Yu.E., Ilyina I.Yu., Goncharov I.Yu.<br>
<br>
Pirogov Russian National Research Medical University, Moscow<br>
<br>
Uterine myoma occupies one of the leading positions in the structure of gynecological diseases among the women of childbearing age. If the woman with uterine myoma have no indications for the surgical treatment, then it is necessary to consider the question of alternative methods of treatment. The role of progesterone in the development of uterine myoma provides enough justification for the use of antigestagens in the therapy of this disease.<br>
<b>The aim </b>of the study was to evaluate the effectiveness of Gynestril<sup>®</sup> at a dose of 50 mg / daily when used in the treatment of symptomatic uterine myoma with the size of up to 12 weeks of conditional pregnancy.<br>
<b>Patients and Methods:</b> The study involved 60 female patients with symptomatic uterine myoma with the size of up to 12 weeks of conditional pregnancy. Patients were divided into groups: group 1 (n = 30) received Gynestril<sup>®</sup> at a dose of 50 mg daily for 6 months, treatment started on the second day of the menstrual cycle. Group 2 (n = 30) received buserelin in injections according to the standard scheme for 6 months. During a complex examination, in addition to clinical and anamnestic methods, instrumental and laboratory methods were used: ultrasound examination of pelvic organs, hormonal profile, hysteroscopy. The effectiveness of the therapy was evaluated after 3 and 6 months of treatment, after 3 and 6 months of finishing the drug intaking.<br>
<b>Results</b>: the use of Gynestril<sup>®</sup> provides less pronounced changes in the decrease of the uterine size as compared to buserelin, but it has a longer effect after treatment.<br>
Conclusion: clinical efficacy and good tolerability of the Gynestril<sup>®</sup> allows its successful use for the treatment of the uterine myoma in women of reproductive age.<br>
<br>
<b>Key words:</b> uterine myoma, medication, hysteroscopy, ultrasound, uterine size, estradiol, progesterone, buserelin, mifepristone, Gynestril.<br>
<b>For citation:</b> Dobrokhotova Yu.E., lyina I.Yu., Goncharov I.Yu. Uterine myoma. Non-surgical treatment // RMJ. 2018. № 2(I). P. 3–6.<br> |
| first_indexed | 2024-03-07T21:39:38Z |
| format | Article |
| id | doaj.art-84e453fb0aa44f3e81919ca6606f3186 |
| institution | Directory Open Access Journal |
| issn | 2618-8430 2686-7184 |
| language | Russian |
| last_indexed | 2024-03-07T21:39:38Z |
| publishDate | 2018-02-01 |
| publisher | LCC «Medicine-Inform» |
| record_format | Article |
| series | РМЖ. Мать и дитя |
| spelling | doaj.art-84e453fb0aa44f3e81919ca6606f31862024-02-26T10:13:30ZrusLCC «Medicine-Inform»РМЖ. Мать и дитя2618-84302686-71842018-02-01262(I)32139Uterine myoma. Non-surgical treatmentYu.E. Dobrokhotova0Ilina I.Yu.1Goncharov I.Yu.2Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<b>Uterine myoma. Non-surgical treatment </b><br> Dobrokhotova Yu.E., Ilyina I.Yu., Goncharov I.Yu.<br> <br> Pirogov Russian National Research Medical University, Moscow<br> <br> Uterine myoma occupies one of the leading positions in the structure of gynecological diseases among the women of childbearing age. If the woman with uterine myoma have no indications for the surgical treatment, then it is necessary to consider the question of alternative methods of treatment. The role of progesterone in the development of uterine myoma provides enough justification for the use of antigestagens in the therapy of this disease.<br> <b>The aim </b>of the study was to evaluate the effectiveness of Gynestril<sup>®</sup> at a dose of 50 mg / daily when used in the treatment of symptomatic uterine myoma with the size of up to 12 weeks of conditional pregnancy.<br> <b>Patients and Methods:</b> The study involved 60 female patients with symptomatic uterine myoma with the size of up to 12 weeks of conditional pregnancy. Patients were divided into groups: group 1 (n = 30) received Gynestril<sup>®</sup> at a dose of 50 mg daily for 6 months, treatment started on the second day of the menstrual cycle. Group 2 (n = 30) received buserelin in injections according to the standard scheme for 6 months. During a complex examination, in addition to clinical and anamnestic methods, instrumental and laboratory methods were used: ultrasound examination of pelvic organs, hormonal profile, hysteroscopy. The effectiveness of the therapy was evaluated after 3 and 6 months of treatment, after 3 and 6 months of finishing the drug intaking.<br> <b>Results</b>: the use of Gynestril<sup>®</sup> provides less pronounced changes in the decrease of the uterine size as compared to buserelin, but it has a longer effect after treatment.<br> Conclusion: clinical efficacy and good tolerability of the Gynestril<sup>®</sup> allows its successful use for the treatment of the uterine myoma in women of reproductive age.<br> <br> <b>Key words:</b> uterine myoma, medication, hysteroscopy, ultrasound, uterine size, estradiol, progesterone, buserelin, mifepristone, Gynestril.<br> <b>For citation:</b> Dobrokhotova Yu.E., lyina I.Yu., Goncharov I.Yu. Uterine myoma. Non-surgical treatment // RMJ. 2018. № 2(I). P. 3–6.<br>http://wchjournal.com/upload/iblock/d6d/d6da1eaac870e03be0b537857186915b.pdf |
| spellingShingle | Yu.E. Dobrokhotova Ilina I.Yu. Goncharov I.Yu. Uterine myoma. Non-surgical treatment РМЖ. Мать и дитя |
| title | Uterine myoma. Non-surgical treatment |
| title_full | Uterine myoma. Non-surgical treatment |
| title_fullStr | Uterine myoma. Non-surgical treatment |
| title_full_unstemmed | Uterine myoma. Non-surgical treatment |
| title_short | Uterine myoma. Non-surgical treatment |
| title_sort | uterine myoma non surgical treatment |
| url | http://wchjournal.com/upload/iblock/d6d/d6da1eaac870e03be0b537857186915b.pdf |
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