Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years
Abstract Background Prolonged electrocardiogram (ECG) QRS duration has been associated with increased cardiovascular risk. It is unclear whether the main predictor of cardiovascular risk, the Framingham risk score also predicts short-term changes in ECG QRS duration. Our aim is to determine whether...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | International Journal of Arrhythmia |
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| Online Access: | https://doi.org/10.1186/s42444-020-00024-6 |
| _version_ | 1830189525647753216 |
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| author | Elijah Stone Yuling Zhou Herbert Jelinek Craig S. Mclachlan |
| author_facet | Elijah Stone Yuling Zhou Herbert Jelinek Craig S. Mclachlan |
| author_sort | Elijah Stone |
| collection | DOAJ |
| description | Abstract Background Prolonged electrocardiogram (ECG) QRS duration has been associated with increased cardiovascular risk. It is unclear whether the main predictor of cardiovascular risk, the Framingham risk score also predicts short-term changes in ECG QRS duration. Our aim is to determine whether baseline Framingham risk score is associated with baseline or changes in QRS duration. Methods A retrospective cross-sectional analysis was performed using observational data obtained from two hundred two participants. Framingham risk score was calculated using an online risk calculator. QRS duration was obtained using a 10 s trace from a Welch Allyn PC-based 12-lead ECG system. Results Average follow-up duration was 3.3 ± 1.1 years. Mean QRS change was 1.8 ± 11.4 ms. Specifically, among two hundred two participants, there are 104 subjects with a greater QRS duration at follow-up, while 98 subjects had the same or a shorter follow-up QRS duration. Baseline Framingham risk score did not significantly predict an increase in QRSd with an odds ratio of 1.04 (P = 0.230). Regression analysis of QRS duration at baseline and Framingham risk at baseline had a weak association (R 2 = 0.020; P = 0.043). The Framingham risk score at follow-up was likewise has a weak association with follow-up QRS duration (R 2 = 0.045; P = 0.002). Conclusions Our results do not demonstrate a statistically significant association between Framingham risk parameters and future QRS duration changes over longitudinal time. QRS duration had variable changes between baseline and follow-up. This might suggest that a longer period of follow-up is required to document more stable increases in QRS duration associated with ventricular pathology. A larger population study is needed to confirm our observations. |
| first_indexed | 2024-12-17T23:04:32Z |
| format | Article |
| id | doaj.art-84e49f202a58478fa8679ae227593789 |
| institution | Directory Open Access Journal |
| issn | 2466-1171 |
| language | English |
| last_indexed | 2024-12-17T23:04:32Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Arrhythmia |
| spelling | doaj.art-84e49f202a58478fa8679ae2275937892022-12-21T21:29:19ZengBMCInternational Journal of Arrhythmia2466-11712020-10-012111610.1186/s42444-020-00024-6Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 yearsElijah Stone0Yuling Zhou1Herbert Jelinek2Craig S. Mclachlan3Rural Clinical School, University of New South WalesXiamen Cardiovascular Hospital, Xiamen UniversityHealth Sciences, Charles Sturt UniversityCentre for Healthy Futures, Health Faculty, Torrens University Australia, Pyrmont Campus, SydneyAbstract Background Prolonged electrocardiogram (ECG) QRS duration has been associated with increased cardiovascular risk. It is unclear whether the main predictor of cardiovascular risk, the Framingham risk score also predicts short-term changes in ECG QRS duration. Our aim is to determine whether baseline Framingham risk score is associated with baseline or changes in QRS duration. Methods A retrospective cross-sectional analysis was performed using observational data obtained from two hundred two participants. Framingham risk score was calculated using an online risk calculator. QRS duration was obtained using a 10 s trace from a Welch Allyn PC-based 12-lead ECG system. Results Average follow-up duration was 3.3 ± 1.1 years. Mean QRS change was 1.8 ± 11.4 ms. Specifically, among two hundred two participants, there are 104 subjects with a greater QRS duration at follow-up, while 98 subjects had the same or a shorter follow-up QRS duration. Baseline Framingham risk score did not significantly predict an increase in QRSd with an odds ratio of 1.04 (P = 0.230). Regression analysis of QRS duration at baseline and Framingham risk at baseline had a weak association (R 2 = 0.020; P = 0.043). The Framingham risk score at follow-up was likewise has a weak association with follow-up QRS duration (R 2 = 0.045; P = 0.002). Conclusions Our results do not demonstrate a statistically significant association between Framingham risk parameters and future QRS duration changes over longitudinal time. QRS duration had variable changes between baseline and follow-up. This might suggest that a longer period of follow-up is required to document more stable increases in QRS duration associated with ventricular pathology. A larger population study is needed to confirm our observations.https://doi.org/10.1186/s42444-020-00024-6ECGQRS durationFramingham risk scorePopulation studyRural |
| spellingShingle | Elijah Stone Yuling Zhou Herbert Jelinek Craig S. Mclachlan Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years International Journal of Arrhythmia ECG QRS duration Framingham risk score Population study Rural |
| title | Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years |
| title_full | Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years |
| title_fullStr | Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years |
| title_full_unstemmed | Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years |
| title_short | Baseline Framingham risk score does not predict future ECG-derived QRS duration over an average of 3.3 years |
| title_sort | baseline framingham risk score does not predict future ecg derived qrs duration over an average of 3 3 years |
| topic | ECG QRS duration Framingham risk score Population study Rural |
| url | https://doi.org/10.1186/s42444-020-00024-6 |
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