Protective role of Crocin against nicotine-induced damages on male mice liver
Background: Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in liver and causes devastating effects. Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=92;epage=92;aulast=Jalili |
| _version_ | 1818298920806121472 |
|---|---|
| author | Cyrus Jalili Hadis Tabatabaei Seyran Kakaberiei Shiva Roshankhah Mohammad Reza Salahshoor |
| author_facet | Cyrus Jalili Hadis Tabatabaei Seyran Kakaberiei Shiva Roshankhah Mohammad Reza Salahshoor |
| author_sort | Cyrus Jalili |
| collection | DOAJ |
| description | Background: Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in liver and causes devastating effects. Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant and anticancer. This study was designed to evaluate the protective role of crocin against nicotine on the liver of mice.
Methods: Forty-eight mice were equally divided into 8 groups; control (normal saline), nicotine (2.5 mg/kg), crocin (12.5, 25 and 50 mg/kg) and crocin plus nicotine treated groups. Saline, crocin, nicotine and crocin/nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied.
Results: The results indicated that nicotine administration significantly decreased liver weight (48.37%) and increased the mean diameter of hepatocyte (239%), central hepatic vein (28.45%), liver enzymes level (ALP 29.43%, AST 21.81%, ALT 21.55%), and blood serum nitric oxide level (57.18%) compared to saline group (P < 0.05). However, crocin and crocin plus nicotine administration significantly boosted liver weight (49.54%) and decreased the mean diameter of hepatocyte (40.48%), central hepatic vein (15.44%), liver enzymes (ALP 22.02%, AST 19.05%, ALT 23.11%), and nitric oxide levels (35.80%) in all groups compared to nicotine group (percentages represent the maximum dose) (P < 0.05).
Conclusions: Crocin showed its partly protective effect against nicotine-induced liver toxicity. |
| first_indexed | 2024-12-13T04:43:00Z |
| format | Article |
| id | doaj.art-84e4bbf8887e485b8bbf0a35700c1e22 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-12-13T04:43:00Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-84e4bbf8887e485b8bbf0a35700c1e222022-12-21T23:59:15ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132015-01-0161929210.4103/2008-7802.165203Protective role of Crocin against nicotine-induced damages on male mice liverCyrus JaliliHadis TabatabaeiSeyran KakaberieiShiva RoshankhahMohammad Reza SalahshoorBackground: Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in liver and causes devastating effects. Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant and anticancer. This study was designed to evaluate the protective role of crocin against nicotine on the liver of mice. Methods: Forty-eight mice were equally divided into 8 groups; control (normal saline), nicotine (2.5 mg/kg), crocin (12.5, 25 and 50 mg/kg) and crocin plus nicotine treated groups. Saline, crocin, nicotine and crocin/nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied. Results: The results indicated that nicotine administration significantly decreased liver weight (48.37%) and increased the mean diameter of hepatocyte (239%), central hepatic vein (28.45%), liver enzymes level (ALP 29.43%, AST 21.81%, ALT 21.55%), and blood serum nitric oxide level (57.18%) compared to saline group (P < 0.05). However, crocin and crocin plus nicotine administration significantly boosted liver weight (49.54%) and decreased the mean diameter of hepatocyte (40.48%), central hepatic vein (15.44%), liver enzymes (ALP 22.02%, AST 19.05%, ALT 23.11%), and nitric oxide levels (35.80%) in all groups compared to nicotine group (percentages represent the maximum dose) (P < 0.05). Conclusions: Crocin showed its partly protective effect against nicotine-induced liver toxicity.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=92;epage=92;aulast=JaliliCrocinlivermicenicotine |
| spellingShingle | Cyrus Jalili Hadis Tabatabaei Seyran Kakaberiei Shiva Roshankhah Mohammad Reza Salahshoor Protective role of Crocin against nicotine-induced damages on male mice liver International Journal of Preventive Medicine Crocin liver mice nicotine |
| title | Protective role of Crocin against nicotine-induced damages on male mice liver |
| title_full | Protective role of Crocin against nicotine-induced damages on male mice liver |
| title_fullStr | Protective role of Crocin against nicotine-induced damages on male mice liver |
| title_full_unstemmed | Protective role of Crocin against nicotine-induced damages on male mice liver |
| title_short | Protective role of Crocin against nicotine-induced damages on male mice liver |
| title_sort | protective role of crocin against nicotine induced damages on male mice liver |
| topic | Crocin liver mice nicotine |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=92;epage=92;aulast=Jalili |
| work_keys_str_mv | AT cyrusjalili protectiveroleofcrocinagainstnicotineinduceddamagesonmalemiceliver AT hadistabatabaei protectiveroleofcrocinagainstnicotineinduceddamagesonmalemiceliver AT seyrankakaberiei protectiveroleofcrocinagainstnicotineinduceddamagesonmalemiceliver AT shivaroshankhah protectiveroleofcrocinagainstnicotineinduceddamagesonmalemiceliver AT mohammadrezasalahshoor protectiveroleofcrocinagainstnicotineinduceddamagesonmalemiceliver |