Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis

Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis

Hyperhomocysteinemia induces stress response in endoplasmic reticulum (ERS). Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by blockage of PERK/eIF2α/ATF4/CHOP signaling. Short-term exposure of vascular smo...

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Bibliographic Details
Main Authors: Wei Li, Fujun Shang, Xiaoli Li, Shaoping Lu, Xiaolin Niu, Zhimin Zhang, Jing Liu, Xue Li, Lianyou Zhao
Format: Article
Language:English
Published: IMR Press 2020-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
homocysteine
vsmcs
salubrinal
endoplasmic reticulum stress
apoptosis
Online Access:https://www.imrpress.com/journal/FBL/25/3/10.2741/4819

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