Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis
ObjectivesShanghai witnessed an unprecedented outbreak of COVID-19 and experienced a strict lockdown from March 28, 2022 to May 31, 2022. Most studies to date are on the first lockdown after the outbreak in December 2019. This study aimed to examine the impact of lockdown on delivery and neonatal ou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.992908/full |
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| author | Fang-Yue Zhou Fang-Yue Zhou Cheng Li Kai-Zhou Qin Chuan Luo He-Feng Huang He-Feng Huang He-Feng Huang Yan-Ting Wu |
| author_facet | Fang-Yue Zhou Fang-Yue Zhou Cheng Li Kai-Zhou Qin Chuan Luo He-Feng Huang He-Feng Huang He-Feng Huang Yan-Ting Wu |
| author_sort | Fang-Yue Zhou |
| collection | DOAJ |
| description | ObjectivesShanghai witnessed an unprecedented outbreak of COVID-19 and experienced a strict lockdown from March 28, 2022 to May 31, 2022. Most studies to date are on the first lockdown after the outbreak in December 2019. This study aimed to examine the impact of lockdown on delivery and neonatal outcomes among uninfected pregnant women in the new phase of the COVID-19 outbreak.MethodsA retrospective analysis was conducted in the Obstetrics and Gynecology Hospital of Fudan University. Pregnant women without COVID-19 who delivered from March 28, 2022 to May 31, 2022 (lockdown group) and the same period in 2021 (non-lockdown group) were recruited for this study. Logistic regression models and 1 : 1 propensity score matching (PSM) were used to assess the effect of lockdown on delivery outcomes.ResultsA total of 2,962 patients were included in this study, 1,339 of whom were from the lockdown group. Compared with the non-lockdown group, pregnant women giving birth during lockdown had an increased risk of term prelabor rupture of membranes (TPROM) (aOR = 1.253, 95% CI: 1.026–1.530), and decreased risks of postpartum hemorrhage (PPH) (aOR = 0.362, 95% CI: 0.216–0.606) and fetal malformation (aOR = 0.309, 95% CI: 0.164–0.582). The risk of large for gestational age (LGA) (aOR = 0.802, 95% CI: 0.648–0.992) and rate of admission to the neonatal intensive care unit (NICU) (aOR = 0.722, 95% CI: 0.589–0.885) also significantly declined. After 1 : 1 PSM, the impact of lockdown on the risk of TPROM (aOR = 1.501, 95% CI: 1.083–2.080), PPH (aOR = 0.371, 95% CI: 0.211–0.654), fetal malformation (aOR = 0.332, 95% CI: 0.161–0.684), LGA (aOR = 0.749, 95% CI: 0.594–0.945) and rate of admission to the NICU (aOR = 0.700, 95% CI: 0.564–0.869) all remained. There were no other delivery or neonatal outcomes affected by the lockdown after the COVID-19 outbreak.ConclusionThis study indicated a significant increase in the risk of term PROM, significant decreases in the risk of PPH, fetal malformation and LGA, and a marked decline in the rate of admission to the NICU during Shanghai Lockdown. |
| first_indexed | 2024-04-10T18:06:09Z |
| format | Article |
| id | doaj.art-84e53fda8e67481eadc9d52511daaf87 |
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| language | English |
| last_indexed | 2024-04-10T18:06:09Z |
| publishDate | 2023-02-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-84e53fda8e67481eadc9d52511daaf872023-02-02T12:58:44ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-02-011110.3389/fped.2023.992908992908Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysisFang-Yue Zhou0Fang-Yue Zhou1Cheng Li2Kai-Zhou Qin3Chuan Luo4He-Feng Huang5He-Feng Huang6He-Feng Huang7Yan-Ting Wu8Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaResearch Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU056), Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaObjectivesShanghai witnessed an unprecedented outbreak of COVID-19 and experienced a strict lockdown from March 28, 2022 to May 31, 2022. Most studies to date are on the first lockdown after the outbreak in December 2019. This study aimed to examine the impact of lockdown on delivery and neonatal outcomes among uninfected pregnant women in the new phase of the COVID-19 outbreak.MethodsA retrospective analysis was conducted in the Obstetrics and Gynecology Hospital of Fudan University. Pregnant women without COVID-19 who delivered from March 28, 2022 to May 31, 2022 (lockdown group) and the same period in 2021 (non-lockdown group) were recruited for this study. Logistic regression models and 1 : 1 propensity score matching (PSM) were used to assess the effect of lockdown on delivery outcomes.ResultsA total of 2,962 patients were included in this study, 1,339 of whom were from the lockdown group. Compared with the non-lockdown group, pregnant women giving birth during lockdown had an increased risk of term prelabor rupture of membranes (TPROM) (aOR = 1.253, 95% CI: 1.026–1.530), and decreased risks of postpartum hemorrhage (PPH) (aOR = 0.362, 95% CI: 0.216–0.606) and fetal malformation (aOR = 0.309, 95% CI: 0.164–0.582). The risk of large for gestational age (LGA) (aOR = 0.802, 95% CI: 0.648–0.992) and rate of admission to the neonatal intensive care unit (NICU) (aOR = 0.722, 95% CI: 0.589–0.885) also significantly declined. After 1 : 1 PSM, the impact of lockdown on the risk of TPROM (aOR = 1.501, 95% CI: 1.083–2.080), PPH (aOR = 0.371, 95% CI: 0.211–0.654), fetal malformation (aOR = 0.332, 95% CI: 0.161–0.684), LGA (aOR = 0.749, 95% CI: 0.594–0.945) and rate of admission to the NICU (aOR = 0.700, 95% CI: 0.564–0.869) all remained. There were no other delivery or neonatal outcomes affected by the lockdown after the COVID-19 outbreak.ConclusionThis study indicated a significant increase in the risk of term PROM, significant decreases in the risk of PPH, fetal malformation and LGA, and a marked decline in the rate of admission to the NICU during Shanghai Lockdown.https://www.frontiersin.org/articles/10.3389/fped.2023.992908/fullCOVID-19lockdowndelivery outcomesprelabor rupture of membranes (PROM)neonatal outcomes |
| spellingShingle | Fang-Yue Zhou Fang-Yue Zhou Cheng Li Kai-Zhou Qin Chuan Luo He-Feng Huang He-Feng Huang He-Feng Huang Yan-Ting Wu Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis Frontiers in Pediatrics COVID-19 lockdown delivery outcomes prelabor rupture of membranes (PROM) neonatal outcomes |
| title | Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis |
| title_full | Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis |
| title_fullStr | Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis |
| title_full_unstemmed | Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis |
| title_short | Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis |
| title_sort | delivery and neonatal outcomes of pregnant women during the shanghai lockdown a retrospective analysis |
| topic | COVID-19 lockdown delivery outcomes prelabor rupture of membranes (PROM) neonatal outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.992908/full |
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