Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers
Background. Brain-computer interface (BCI) devices are being investigated for their application in stroke rehabilitation, but little is known about how structural changes in the motor system relate to behavioral measures with the use of these systems. Objective. This study examined relationships amo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-09-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00457/full |
| _version_ | 1819076230518931456 |
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| author | Brittany Mei Young Julie M Stamm Jie Song Alexander B Remsik Veena A Nair Mitchell E Tyler Dorothy Farrar Edwards Kristin Caldera Justin A Sattin Justin C Williams Vivek Prabhakaran |
| author_facet | Brittany Mei Young Julie M Stamm Jie Song Alexander B Remsik Veena A Nair Mitchell E Tyler Dorothy Farrar Edwards Kristin Caldera Justin A Sattin Justin C Williams Vivek Prabhakaran |
| author_sort | Brittany Mei Young |
| collection | DOAJ |
| description | Background. Brain-computer interface (BCI) devices are being investigated for their application in stroke rehabilitation, but little is known about how structural changes in the motor system relate to behavioral measures with the use of these systems. Objective. This study examined relationships among diffusion tensor imaging (DTI)-derived metrics and with behavioral changes in stroke patients with and without BCI training. Methods. Stroke patients (n=19) with upper extremity motor impairment were assessed using Stroke Impact Scale (SIS), Action Research Arm Test (ARAT), Nine-Hole Peg Test (9-HPT), and DTI scans. Ten subjects completed four assessments over a control period during which no training was administered. Seventeen subjects, including eight who completed the control period, completed four assessments over an experimental period during which subjects received interventional BCI training. Fractional anisotropy (FA) values were extracted from each corticospinal tract (CST) and transcallosal motor fibers for each scan. Results. No significant group by time interactions were identified at the group level in DTI or behavioral measures. During the control period, increases in contralesional CST FA and in asymmetric FA (aFA) correlated with poorer scores on SIS and 9-HPT. During the experimental period (with BCI training), increases in contralesional CST FA were correlated with improvements in 9-HPT while increases in aFA correlated with improvements in ARAT but with worsening 9-HPT performance; changes in transcallosal motor fibers positively correlated with those in the contralesional CST. All correlations p<0.05 corrected. Conclusions. These findings suggest that the integrity of the contralesional CST may be used to track individual behavioral changes observed with BCI training after stroke. |
| first_indexed | 2024-12-21T18:38:00Z |
| format | Article |
| id | doaj.art-84e5a4718a47488f8910c206b092d981 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-21T18:38:00Z |
| publishDate | 2016-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-84e5a4718a47488f8910c206b092d9812022-12-21T18:54:05ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-09-011010.3389/fnhum.2016.00457197914Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor FibersBrittany Mei Young0Julie M Stamm1Jie Song2Alexander B Remsik3Veena A Nair4Mitchell E Tyler5Dorothy Farrar Edwards6Kristin Caldera7Justin A Sattin8Justin C Williams9Vivek Prabhakaran10University of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonBackground. Brain-computer interface (BCI) devices are being investigated for their application in stroke rehabilitation, but little is known about how structural changes in the motor system relate to behavioral measures with the use of these systems. Objective. This study examined relationships among diffusion tensor imaging (DTI)-derived metrics and with behavioral changes in stroke patients with and without BCI training. Methods. Stroke patients (n=19) with upper extremity motor impairment were assessed using Stroke Impact Scale (SIS), Action Research Arm Test (ARAT), Nine-Hole Peg Test (9-HPT), and DTI scans. Ten subjects completed four assessments over a control period during which no training was administered. Seventeen subjects, including eight who completed the control period, completed four assessments over an experimental period during which subjects received interventional BCI training. Fractional anisotropy (FA) values were extracted from each corticospinal tract (CST) and transcallosal motor fibers for each scan. Results. No significant group by time interactions were identified at the group level in DTI or behavioral measures. During the control period, increases in contralesional CST FA and in asymmetric FA (aFA) correlated with poorer scores on SIS and 9-HPT. During the experimental period (with BCI training), increases in contralesional CST FA were correlated with improvements in 9-HPT while increases in aFA correlated with improvements in ARAT but with worsening 9-HPT performance; changes in transcallosal motor fibers positively correlated with those in the contralesional CST. All correlations p<0.05 corrected. Conclusions. These findings suggest that the integrity of the contralesional CST may be used to track individual behavioral changes observed with BCI training after stroke.http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00457/fullDiffusion Tensor ImagingRehabilitationStrokeUpper ExtremityneuroplasticityBrain-computer interface |
| spellingShingle | Brittany Mei Young Julie M Stamm Jie Song Alexander B Remsik Veena A Nair Mitchell E Tyler Dorothy Farrar Edwards Kristin Caldera Justin A Sattin Justin C Williams Vivek Prabhakaran Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers Frontiers in Human Neuroscience Diffusion Tensor Imaging Rehabilitation Stroke Upper Extremity neuroplasticity Brain-computer interface |
| title | Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers |
| title_full | Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers |
| title_fullStr | Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers |
| title_full_unstemmed | Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers |
| title_short | Brain-Computer Interface Therapy after Stroke Affects Patterns of Brain-Behavior Relationships in Corticospinal Motor Fibers |
| title_sort | brain computer interface therapy after stroke affects patterns of brain behavior relationships in corticospinal motor fibers |
| topic | Diffusion Tensor Imaging Rehabilitation Stroke Upper Extremity neuroplasticity Brain-computer interface |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00457/full |
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