Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats
Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) gene...
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| Format: | Article |
| Language: | fas |
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Birjand University of Medical Sciences and Health Services
2021-03-01
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| Series: | مجله دانشگاه علوم پزشکی بیرجند |
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| Online Access: | http://journal.bums.ac.ir/article-1-2883-en.html |
| _version_ | 1818208762815578112 |
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| author | Somayeh Kasraei Seyyed Reza Attarzadeh Hosseini Mehrdad Fathei |
| author_facet | Somayeh Kasraei Seyyed Reza Attarzadeh Hosseini Mehrdad Fathei |
| author_sort | Somayeh Kasraei |
| collection | DOAJ |
| description | Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training.
Materials and Methods: The present experimental study was connected on 16 Wistar male rats, aged 20 months, which were assigned to two groups of resistance training group and control. Resistance training was performed three sessions a week over eight weeks. After dissecting the rats, the soleus and flexor hallucis longus muscles of the rats were extracted to measure the expression of klotho protein and (IGF-1) genes using the real-time polymerase chain reaction technique.
Results: After the resistance training program, Klotho protein in the fast-twitch muscle tissue of the trained rats did not show a significant difference, compared to that in the control group. Furthermore, IGF-1 in the fast-twitch and slow-twitch muscles of the training group did not display a marked difference, compared to that in the control group.
Conclusion: As evidenced by the obtained results, the values of klotho protein and IGF-1 did not improve after a period of resistance training. It can be argued that resistance training should be conducted in longer periods and with different intensities, which should be scrutinized in future research. |
| first_indexed | 2024-12-12T04:49:58Z |
| format | Article |
| id | doaj.art-84e5e80535db4b1bb6b0189031ca91d4 |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-12-12T04:49:58Z |
| publishDate | 2021-03-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-84e5e80535db4b1bb6b0189031ca91d42022-12-22T00:37:30ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522021-03-012814050Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar ratsSomayeh Kasraei0Seyyed Reza Attarzadeh Hosseini1Mehrdad Fathei2 Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training. Materials and Methods: The present experimental study was connected on 16 Wistar male rats, aged 20 months, which were assigned to two groups of resistance training group and control. Resistance training was performed three sessions a week over eight weeks. After dissecting the rats, the soleus and flexor hallucis longus muscles of the rats were extracted to measure the expression of klotho protein and (IGF-1) genes using the real-time polymerase chain reaction technique. Results: After the resistance training program, Klotho protein in the fast-twitch muscle tissue of the trained rats did not show a significant difference, compared to that in the control group. Furthermore, IGF-1 in the fast-twitch and slow-twitch muscles of the training group did not display a marked difference, compared to that in the control group. Conclusion: As evidenced by the obtained results, the values of klotho protein and IGF-1 did not improve after a period of resistance training. It can be argued that resistance training should be conducted in longer periods and with different intensities, which should be scrutinized in future research.http://journal.bums.ac.ir/article-1-2883-en.htmlelderlyinsulin-like growth factor 1klotho proteinresistance training |
| spellingShingle | Somayeh Kasraei Seyyed Reza Attarzadeh Hosseini Mehrdad Fathei Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats مجله دانشگاه علوم پزشکی بیرجند elderly insulin-like growth factor 1 klotho protein resistance training |
| title | Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats |
| title_full | Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats |
| title_fullStr | Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats |
| title_full_unstemmed | Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats |
| title_short | Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats |
| title_sort | effect of eight weeks of resistance training on the expression of klotho protein and insulin like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged wistar rats |
| topic | elderly insulin-like growth factor 1 klotho protein resistance training |
| url | http://journal.bums.ac.ir/article-1-2883-en.html |
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