Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study
Background: Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β) are among the cytokines released secondary to the surgical stress response. The objective of this study was to investigate the effect of a Transversus Abdominis Plane (TAP) block on postoperative pain and its immunomodulatory act...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Brazilian Journal of Anesthesiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001421000142 |
| _version_ | 1818026864126459904 |
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| author | Ebru Canakci Murat Cihan Ali Altinbas Zubeyir Cebeci Ahmet Gultekin Nilay Tas |
| author_facet | Ebru Canakci Murat Cihan Ali Altinbas Zubeyir Cebeci Ahmet Gultekin Nilay Tas |
| author_sort | Ebru Canakci |
| collection | DOAJ |
| description | Background: Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β) are among the cytokines released secondary to the surgical stress response. The objective of this study was to investigate the effect of a Transversus Abdominis Plane (TAP) block on postoperative pain and its immunomodulatory activity through proinflammatory cytokines. Methods: TAP (study group; n = 40) or p-TAP (placebo group; n = 40). Patients in the TAP group underwent an Ultrasound (US) guided unilateral TAP block using 20-cc 0.5% bupivacaine solution. Patients in the p-TAP group underwent a sham block using 20-cc isotonic solution. The TNF-α and IL-1β levels were measured three times at preoperative hour-0 and postoperative hours 4 and 24. Visual Analog Scale (VAS) scores were recorded at 0-hours, 30-minutes, 4-hours, and 24-hours. Analgesic use within the first 24-hours following surgery was monitored. Results: The postoperative VAS score was decreased in the TAP group at all time points (0, 4, and 24 hours), and the differences between groups were statistically significant (p < 0.001 for all comparisons). In the TAP group, the TNF-α and IL-1β levels at 4 and 24 hours post operation were significantly lower than the preoperative levels (p < 0.001 for all comparisons). Conclusion: The TAP block for pre-emptive analgesia enabled effective hemodynamic control during the intraoperative period, provided effective pain control in the postoperative period, and decreased inflammation and surgical stress due to the decreased levels of the proinflammatory cytokines TNF-α and IL-1β in the first postoperative 24 hours, indicating immunomodulatory effect. |
| first_indexed | 2024-12-10T04:38:46Z |
| format | Article |
| id | doaj.art-84e6d699ab15451f90e700d00cf40c82 |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-12-10T04:38:46Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-84e6d699ab15451f90e700d00cf40c822022-12-22T02:01:57ZengElsevierBrazilian Journal of Anesthesiology0104-00142021-09-01715538544Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled studyEbru Canakci0Murat Cihan1Ali Altinbas2Zubeyir Cebeci3Ahmet Gultekin4Nilay Tas5Ordu University, School of Medicine, Department of Anesthesiology and Reanimation, Ordu, Turkey; Corresponding author.Ordu University, School of Medicine, Department of Medical Biochemistry, Ordu, TurkeyOrdu University, School of Medicine, Department of Anesthesiology and Reanimation, Ordu, TurkeyOrdu University, School of Medicine, Department of Anesthesiology and Reanimation, Ordu, TurkeyNamık Kemal University, School of Medicine, Department of Anesthesiology and Reanimation, Tekirdağ, TurkeyOrdu University, School of Medicine, Department of Anesthesiology and Reanimation, Ordu, TurkeyBackground: Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β) are among the cytokines released secondary to the surgical stress response. The objective of this study was to investigate the effect of a Transversus Abdominis Plane (TAP) block on postoperative pain and its immunomodulatory activity through proinflammatory cytokines. Methods: TAP (study group; n = 40) or p-TAP (placebo group; n = 40). Patients in the TAP group underwent an Ultrasound (US) guided unilateral TAP block using 20-cc 0.5% bupivacaine solution. Patients in the p-TAP group underwent a sham block using 20-cc isotonic solution. The TNF-α and IL-1β levels were measured three times at preoperative hour-0 and postoperative hours 4 and 24. Visual Analog Scale (VAS) scores were recorded at 0-hours, 30-minutes, 4-hours, and 24-hours. Analgesic use within the first 24-hours following surgery was monitored. Results: The postoperative VAS score was decreased in the TAP group at all time points (0, 4, and 24 hours), and the differences between groups were statistically significant (p < 0.001 for all comparisons). In the TAP group, the TNF-α and IL-1β levels at 4 and 24 hours post operation were significantly lower than the preoperative levels (p < 0.001 for all comparisons). Conclusion: The TAP block for pre-emptive analgesia enabled effective hemodynamic control during the intraoperative period, provided effective pain control in the postoperative period, and decreased inflammation and surgical stress due to the decreased levels of the proinflammatory cytokines TNF-α and IL-1β in the first postoperative 24 hours, indicating immunomodulatory effect.http://www.sciencedirect.com/science/article/pii/S0104001421000142ImmunomodulationPain controlProinflammatory cytokinesTransversus abdominis plane block |
| spellingShingle | Ebru Canakci Murat Cihan Ali Altinbas Zubeyir Cebeci Ahmet Gultekin Nilay Tas Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study Brazilian Journal of Anesthesiology Immunomodulation Pain control Proinflammatory cytokines Transversus abdominis plane block |
| title | Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study |
| title_full | Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study |
| title_fullStr | Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study |
| title_full_unstemmed | Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study |
| title_short | Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study |
| title_sort | efficacy of ultrasound guided transversus abdominis plane tap block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines prospective randomized placebo controlled study |
| topic | Immunomodulation Pain control Proinflammatory cytokines Transversus abdominis plane block |
| url | http://www.sciencedirect.com/science/article/pii/S0104001421000142 |
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