UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

The eukaryotic ribosome is essential for cancer cell survival. Perturbation of ribosome biogenesis induces nucleolar stress or ribosomal stress, which restrains cancer growth, as rapidly proliferating cancer cells need more active ribosome biogenesis. In this study, we found that UTP11 plays an impo...

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Bibliographic Details
Main Authors: Yu Gan, Jun Deng, Qian Hao, Yingdan Huang, Tao Han, Jin-Guo Xu, Min Zhao, Litong Yao, Yingying Xu, Jianping Xiong, Hua Lu, Chunmeng Wang, Jiaxiang Chen, Xiang Zhou
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
UTP11
Ribosome biogenesis
Nucleolar stress
p53
SLC7A11
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001064

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