Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity
Nanocomposites based on hydroxyapatite (HAP) are fabricated with/without combining graphene oxide (GO) and silver oxide (Ag2O). All compositions are structurally investigated using x-ray diffraction (XRD). In addition, the lattice parameters were estimated. Lattice constants a and c of hexagonal HAP...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422010547 |
| _version_ | 1797991977053061120 |
|---|---|
| author | Fahad D. Algahtani Radi Alsafi Helal F. Al-Harthi Najm Eldinn Elsser Elhassan Soufien Gdaim Mohamed T. Elabbasy M.M. El-Desoky M.K. Ahmed |
| author_facet | Fahad D. Algahtani Radi Alsafi Helal F. Al-Harthi Najm Eldinn Elsser Elhassan Soufien Gdaim Mohamed T. Elabbasy M.M. El-Desoky M.K. Ahmed |
| author_sort | Fahad D. Algahtani |
| collection | DOAJ |
| description | Nanocomposites based on hydroxyapatite (HAP) are fabricated with/without combining graphene oxide (GO) and silver oxide (Ag2O). All compositions are structurally investigated using x-ray diffraction (XRD). In addition, the lattice parameters were estimated. Lattice constants a and c of hexagonal HAP symmetry are around 9.42 and 6.88 Å, respectively. Further, the lattice constant of Ag2O is around 4.736 Å. Moreover, Fourier-transform infrared (FTIR) spectroscopy is used besides X-ray photoelectron (XPS) to investigate the composition. The morphological study was done with the scanning electron microscope (SEM) and transmission electron microscope (TEM). In this regard, Ag2O is exhibited as nano-spherical grains, while HAP was shown in nanorod grains. The dimensions of HAP decreased from 39 to 16 to 34 and 7 nm for length and diameter. The average roughness parameter (Ra) increased from 23.3 to 67.5 nm from HAP to TNC. The parameters of average maximum height (Rtm), maximum peak height (Rp), and maximum valley depth (Rv) reached 439.3, 261.3, and 251.8 nm respectively. Further, the Ca/P ratio is detected with a value of 1.5. Besides, cell viability of osteoblast cell lines increased from 95.9 ± 3 to 101.2 ± 5%. In addition, the antibacterial behavior increased to 21.6 ± 2.3 and 21.1 ± 1.4 mm for TNC against Escherichia coli and Staphylococcus aureus, respectively. |
| first_indexed | 2024-04-11T09:00:36Z |
| format | Article |
| id | doaj.art-84ea84d0e47446fe84d0c029020fd900 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-04-11T09:00:36Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-84ea84d0e47446fe84d0c029020fd9002022-12-22T04:32:47ZengElsevierJournal of Materials Research and Technology2238-78542022-09-01206072Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activityFahad D. Algahtani0Radi Alsafi1Helal F. Al-Harthi2Najm Eldinn Elsser Elhassan3Soufien Gdaim4Mohamed T. Elabbasy5M.M. El-Desoky6M.K. Ahmed7Department of Public Health, College of Public Health and Health Informatics, University of Ha'il, Ha'il, 2440, Saudi ArabiaDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi ArabiaBiology Department, Turabah University College, Taif University, 21995, Saudi ArabiaDepartment of Public Health, College of Public Health and Health Informatics, University of Ha'il, Ha'il, 2440, Saudi ArabiaLaboratory of Electronics and Microelectronics, Faculty of Sciences, University of Monastir, TunisiaDepartment of Public Health, College of Public Health and Health Informatics, University of Ha'il, Ha'il, 2440, Saudi Arabia; Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, EgyptDepartment of Physics, Faculty of Science, Suez University, Suez, 43518, EgyptDepartment of Physics, Faculty of Science, Suez University, Suez, 43518, Egypt; Faculty of Nanotechnology for Postgraduate Studies, Cairo University, El-Sheikh Zayed, 12588, Egypt; Corresponding author.Nanocomposites based on hydroxyapatite (HAP) are fabricated with/without combining graphene oxide (GO) and silver oxide (Ag2O). All compositions are structurally investigated using x-ray diffraction (XRD). In addition, the lattice parameters were estimated. Lattice constants a and c of hexagonal HAP symmetry are around 9.42 and 6.88 Å, respectively. Further, the lattice constant of Ag2O is around 4.736 Å. Moreover, Fourier-transform infrared (FTIR) spectroscopy is used besides X-ray photoelectron (XPS) to investigate the composition. The morphological study was done with the scanning electron microscope (SEM) and transmission electron microscope (TEM). In this regard, Ag2O is exhibited as nano-spherical grains, while HAP was shown in nanorod grains. The dimensions of HAP decreased from 39 to 16 to 34 and 7 nm for length and diameter. The average roughness parameter (Ra) increased from 23.3 to 67.5 nm from HAP to TNC. The parameters of average maximum height (Rtm), maximum peak height (Rp), and maximum valley depth (Rv) reached 439.3, 261.3, and 251.8 nm respectively. Further, the Ca/P ratio is detected with a value of 1.5. Besides, cell viability of osteoblast cell lines increased from 95.9 ± 3 to 101.2 ± 5%. In addition, the antibacterial behavior increased to 21.6 ± 2.3 and 21.1 ± 1.4 mm for TNC against Escherichia coli and Staphylococcus aureus, respectively.http://www.sciencedirect.com/science/article/pii/S2238785422010547Ag2OGraphene oxideHydroxyapatiteAntibacterialTernary nanocomposite |
| spellingShingle | Fahad D. Algahtani Radi Alsafi Helal F. Al-Harthi Najm Eldinn Elsser Elhassan Soufien Gdaim Mohamed T. Elabbasy M.M. El-Desoky M.K. Ahmed Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity Journal of Materials Research and Technology Ag2O Graphene oxide Hydroxyapatite Antibacterial Ternary nanocomposite |
| title | Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity |
| title_full | Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity |
| title_fullStr | Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity |
| title_full_unstemmed | Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity |
| title_short | Development of ternary nanocomposites based on hydroxyapatite/silver oxide for biomedical applications: morphology, structure and antibacterial activity |
| title_sort | development of ternary nanocomposites based on hydroxyapatite silver oxide for biomedical applications morphology structure and antibacterial activity |
| topic | Ag2O Graphene oxide Hydroxyapatite Antibacterial Ternary nanocomposite |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422010547 |
| work_keys_str_mv | AT fahaddalgahtani developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT radialsafi developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT helalfalharthi developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT najmeldinnelsserelhassan developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT soufiengdaim developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT mohamedtelabbasy developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT mmeldesoky developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity AT mkahmed developmentofternarynanocompositesbasedonhydroxyapatitesilveroxideforbiomedicalapplicationsmorphologystructureandantibacterialactivity |