Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study
Background: Type 2 diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) have been associated, according to various epidemiological research. This study uses Mendelian randomization (MR) to investigate the causal link between T2DM and IBD.Methods: To investigate the causal relationship betwe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1325401/full |
| _version_ | 1827349018547585024 |
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| author | Ling-tong Tang Lei Feng Hui-ying Cao Rui Shi Bei-bei Luo Yan-bi Zhang Yan-mei Liu Jian Zhang Shuang-yue Li |
| author_facet | Ling-tong Tang Lei Feng Hui-ying Cao Rui Shi Bei-bei Luo Yan-bi Zhang Yan-mei Liu Jian Zhang Shuang-yue Li |
| author_sort | Ling-tong Tang |
| collection | DOAJ |
| description | Background: Type 2 diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) have been associated, according to various epidemiological research. This study uses Mendelian randomization (MR) to investigate the causal link between T2DM and IBD.Methods: To investigate the causal relationship between IBD and T2DM risk using European population data from the genome-wide association study (GWAS) summary datasets, we constructed a two-sample MR study to evaluate the genetically predicted impacts of liability towards IBD outcomes on T2DM risk. As instrumental variables (IVs), we chose 26 single nucleotide polymorphisms (SNPs) associated with IBD exposure data. The European T2DM GWAS data was obtained from the IEU OpenGWAS Project database, which contains 298,957 cases as the outcome data. The causal relationship between T2DM and IBD using a reverse MR analysis was also performed.Results: The two-sample MR analysis, with the Bonferroni adjustment for multiple testing, revealed that T2DM risk in Europeans is unaffected by their IBD liability (odds ratio (OR): 0.950–1.066, 95% confidence interval (CI): 0.885–1.019, p = 0.152–0.926). The effects of liability to T2DM on IBD were not supported by the reverse MR analysis either (OR: 0.739–1.131, 95% confidence interval (CI): 0.651–1.100, p = 0.058–0.832). MR analysis of IBS on T2DM also have no significant causal relationship (OR: 0.003–1.007, 95% confidence interval (CI): 1.013–5.791, p = 0.069–0.790). FUMA precisely mapped 22 protein-coding genes utilizing significant SNPs of T2DM acquired from GWAS.Conclusion: The MR study showed that the existing evidence did not support the significant causal effect of IBD on T2DM, nor did it support the causal impact of T2DM on IBD. |
| first_indexed | 2024-03-08T00:22:04Z |
| format | Article |
| id | doaj.art-84ead373ab0647f2b219f0e8fb105863 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-08T00:22:04Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj.art-84ead373ab0647f2b219f0e8fb1058632024-02-16T04:51:36ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-02-011510.3389/fgene.2024.13254011325401Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization studyLing-tong Tang0Lei Feng1Hui-ying Cao2Rui Shi3Bei-bei Luo4Yan-bi Zhang5Yan-mei Liu6Jian Zhang7Shuang-yue Li8Department of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaBackground: Type 2 diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) have been associated, according to various epidemiological research. This study uses Mendelian randomization (MR) to investigate the causal link between T2DM and IBD.Methods: To investigate the causal relationship between IBD and T2DM risk using European population data from the genome-wide association study (GWAS) summary datasets, we constructed a two-sample MR study to evaluate the genetically predicted impacts of liability towards IBD outcomes on T2DM risk. As instrumental variables (IVs), we chose 26 single nucleotide polymorphisms (SNPs) associated with IBD exposure data. The European T2DM GWAS data was obtained from the IEU OpenGWAS Project database, which contains 298,957 cases as the outcome data. The causal relationship between T2DM and IBD using a reverse MR analysis was also performed.Results: The two-sample MR analysis, with the Bonferroni adjustment for multiple testing, revealed that T2DM risk in Europeans is unaffected by their IBD liability (odds ratio (OR): 0.950–1.066, 95% confidence interval (CI): 0.885–1.019, p = 0.152–0.926). The effects of liability to T2DM on IBD were not supported by the reverse MR analysis either (OR: 0.739–1.131, 95% confidence interval (CI): 0.651–1.100, p = 0.058–0.832). MR analysis of IBS on T2DM also have no significant causal relationship (OR: 0.003–1.007, 95% confidence interval (CI): 1.013–5.791, p = 0.069–0.790). FUMA precisely mapped 22 protein-coding genes utilizing significant SNPs of T2DM acquired from GWAS.Conclusion: The MR study showed that the existing evidence did not support the significant causal effect of IBD on T2DM, nor did it support the causal impact of T2DM on IBD.https://www.frontiersin.org/articles/10.3389/fgene.2024.1325401/fullMendelian randomizationtype 2 diabetes mellitusinflammatory bowel diseaseirritable bowel syndromecausal relationship |
| spellingShingle | Ling-tong Tang Lei Feng Hui-ying Cao Rui Shi Bei-bei Luo Yan-bi Zhang Yan-mei Liu Jian Zhang Shuang-yue Li Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study Frontiers in Genetics Mendelian randomization type 2 diabetes mellitus inflammatory bowel disease irritable bowel syndrome causal relationship |
| title | Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study |
| title_full | Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study |
| title_fullStr | Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study |
| title_full_unstemmed | Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study |
| title_short | Investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus: a Mendelian randomization study |
| title_sort | investigation of the causal relationship between inflammatory bowel disease and type 2 diabetes mellitus a mendelian randomization study |
| topic | Mendelian randomization type 2 diabetes mellitus inflammatory bowel disease irritable bowel syndrome causal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1325401/full |
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