White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging
Previous studies have introduced the concept of “SuperAgers,” defined as older adults with youthful memory performance associated with the increased cortical thickness of the anterior cingulate cortex. Given that age-related structural brain changes are observed earlier in the white matter (WM) than...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2020.549983/full |
| _version_ | 1819112255135940608 |
|---|---|
| author | Bori R. Kim Bori R. Kim Hunki Kwon Min Young Chun Kee Duk Park Soo Mee Lim Jee Hyang Jeong Geon Ha Kim |
| author_facet | Bori R. Kim Bori R. Kim Hunki Kwon Min Young Chun Kee Duk Park Soo Mee Lim Jee Hyang Jeong Geon Ha Kim |
| author_sort | Bori R. Kim |
| collection | DOAJ |
| description | Previous studies have introduced the concept of “SuperAgers,” defined as older adults with youthful memory performance associated with the increased cortical thickness of the anterior cingulate cortex. Given that age-related structural brain changes are observed earlier in the white matter (WM) than in the cortical areas, we investigated whether WM integrity is different between the SuperAgers (SA) and typical agers (TA) and whether it is associated with superior memory performance as well as a healthy lifestyle. A total of 35 SA and 55 TA were recruited for this study. Further, 3.0-T magnetic resonance imaging (MRI), neuropsychological tests, and lifestyle factors related to cognitive function, such as physical activity and duration of sleep, were evaluated in all participants. SA was defined as individuals demonstrating the youthful performance of verbal and visual memory, as measured by the Seoul Verbal Learning Test (SVLT) and the Rey-Osterrieth Complex Figure Test (RCFT), respectively. Tract-based spatial statistics (TBSS) analysis was used to compare the diffusion values such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) between the SA and TA. SA exhibited better performance in memory, attention, visuospatial, and frontal executive functions than the TA did. SA also exhibited greater amounts of physical activity than the TA did. As compared to TA, SA demonstrated higher FA with lower MD, RD, and AD in the corpus callosum and higher FA and lower RD in the right superior longitudinal fasciculus (SLF), which is significantly associated with memory function. Interestingly, FA values of the body of corpus callosum were correlated with the amount of physical activity. Our findings suggest that WM integrity of the corpus callosum is associated with superior memory function and a higher level of physical activities in SA compared to TA. |
| first_indexed | 2024-12-22T04:10:36Z |
| format | Article |
| id | doaj.art-84ec150f75b74d1eb822aaef5ef3dc55 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T04:10:36Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-84ec150f75b74d1eb822aaef5ef3dc552022-12-21T18:39:31ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-09-011210.3389/fnagi.2020.549983549983White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-agingBori R. Kim0Bori R. Kim1Hunki Kwon2Min Young Chun3Kee Duk Park4Soo Mee Lim5Jee Hyang Jeong6Geon Ha Kim7Department of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South KoreaEwha Medical Research Institute, Ewha Womans University, Seoul, South KoreaDepartment of Neurology, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South KoreaDepartment of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South KoreaDepartment of Radiology, Ewha Womans University Seoul Hospital, College of Medicine, Ewha Womans University, Seoul, South KoreaDepartment of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South KoreaDepartment of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South KoreaPrevious studies have introduced the concept of “SuperAgers,” defined as older adults with youthful memory performance associated with the increased cortical thickness of the anterior cingulate cortex. Given that age-related structural brain changes are observed earlier in the white matter (WM) than in the cortical areas, we investigated whether WM integrity is different between the SuperAgers (SA) and typical agers (TA) and whether it is associated with superior memory performance as well as a healthy lifestyle. A total of 35 SA and 55 TA were recruited for this study. Further, 3.0-T magnetic resonance imaging (MRI), neuropsychological tests, and lifestyle factors related to cognitive function, such as physical activity and duration of sleep, were evaluated in all participants. SA was defined as individuals demonstrating the youthful performance of verbal and visual memory, as measured by the Seoul Verbal Learning Test (SVLT) and the Rey-Osterrieth Complex Figure Test (RCFT), respectively. Tract-based spatial statistics (TBSS) analysis was used to compare the diffusion values such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) between the SA and TA. SA exhibited better performance in memory, attention, visuospatial, and frontal executive functions than the TA did. SA also exhibited greater amounts of physical activity than the TA did. As compared to TA, SA demonstrated higher FA with lower MD, RD, and AD in the corpus callosum and higher FA and lower RD in the right superior longitudinal fasciculus (SLF), which is significantly associated with memory function. Interestingly, FA values of the body of corpus callosum were correlated with the amount of physical activity. Our findings suggest that WM integrity of the corpus callosum is associated with superior memory function and a higher level of physical activities in SA compared to TA.https://www.frontiersin.org/article/10.3389/fnagi.2020.549983/fulldiffusion tensor imagingwhite matter integritycognitive functionphysical activitysuperAgers |
| spellingShingle | Bori R. Kim Bori R. Kim Hunki Kwon Min Young Chun Kee Duk Park Soo Mee Lim Jee Hyang Jeong Geon Ha Kim White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging Frontiers in Aging Neuroscience diffusion tensor imaging white matter integrity cognitive function physical activity superAgers |
| title | White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging |
| title_full | White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging |
| title_fullStr | White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging |
| title_full_unstemmed | White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging |
| title_short | White Matter Integrity Is Associated With the Amount of Physical Activity in Older Adults With Super-aging |
| title_sort | white matter integrity is associated with the amount of physical activity in older adults with super aging |
| topic | diffusion tensor imaging white matter integrity cognitive function physical activity superAgers |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2020.549983/full |
| work_keys_str_mv | AT borirkim whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT borirkim whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT hunkikwon whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT minyoungchun whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT keedukpark whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT soomeelim whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT jeehyangjeong whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging AT geonhakim whitematterintegrityisassociatedwiththeamountofphysicalactivityinolderadultswithsuperaging |