The Mechanism behind Influenza Virus Cytokine Storm
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-cell communication and viral clearance in the immune system, but excessive cytokines can cause serious immune pathology. Deaths caused by severe influenza are usually related to cytokine storms. The rec...
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MDPI AG
2021-07-01
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Series: | Viruses |
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Online Access: | https://www.mdpi.com/1999-4915/13/7/1362 |
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author | Yinuo Gu Xu Zuo Siyu Zhang Zhuoer Ouyang Shengyu Jiang Fang Wang Guoqiang Wang |
author_facet | Yinuo Gu Xu Zuo Siyu Zhang Zhuoer Ouyang Shengyu Jiang Fang Wang Guoqiang Wang |
author_sort | Yinuo Gu |
collection | DOAJ |
description | Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-cell communication and viral clearance in the immune system, but excessive cytokines can cause serious immune pathology. Deaths caused by severe influenza are usually related to cytokine storms. The recent literature has described the mechanism behind the cytokine–storm network and how it can exacerbate host pathological damage. Biological factors such as sex, age, and obesity may cause biological differences between different individuals, which affects cytokine storms induced by the influenza virus. In this review, we summarize the mechanism behind influenza virus cytokine storms and the differences in cytokine storms of different ages and sexes, and in obesity. |
first_indexed | 2024-03-10T09:19:54Z |
format | Article |
id | doaj.art-84ee313adba74e5aaf46e1a7e62ac918 |
institution | Directory Open Access Journal |
issn | 1999-4915 |
language | English |
last_indexed | 2024-03-10T09:19:54Z |
publishDate | 2021-07-01 |
publisher | MDPI AG |
record_format | Article |
series | Viruses |
spelling | doaj.art-84ee313adba74e5aaf46e1a7e62ac9182023-11-22T05:14:48ZengMDPI AGViruses1999-49152021-07-01137136210.3390/v13071362The Mechanism behind Influenza Virus Cytokine StormYinuo Gu0Xu Zuo1Siyu Zhang2Zhuoer Ouyang3Shengyu Jiang4Fang Wang5Guoqiang Wang6Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaInfluenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-cell communication and viral clearance in the immune system, but excessive cytokines can cause serious immune pathology. Deaths caused by severe influenza are usually related to cytokine storms. The recent literature has described the mechanism behind the cytokine–storm network and how it can exacerbate host pathological damage. Biological factors such as sex, age, and obesity may cause biological differences between different individuals, which affects cytokine storms induced by the influenza virus. In this review, we summarize the mechanism behind influenza virus cytokine storms and the differences in cytokine storms of different ages and sexes, and in obesity.https://www.mdpi.com/1999-4915/13/7/1362influenza viruscytokine stormagesexobesity |
spellingShingle | Yinuo Gu Xu Zuo Siyu Zhang Zhuoer Ouyang Shengyu Jiang Fang Wang Guoqiang Wang The Mechanism behind Influenza Virus Cytokine Storm Viruses influenza virus cytokine storm age sex obesity |
title | The Mechanism behind Influenza Virus Cytokine Storm |
title_full | The Mechanism behind Influenza Virus Cytokine Storm |
title_fullStr | The Mechanism behind Influenza Virus Cytokine Storm |
title_full_unstemmed | The Mechanism behind Influenza Virus Cytokine Storm |
title_short | The Mechanism behind Influenza Virus Cytokine Storm |
title_sort | mechanism behind influenza virus cytokine storm |
topic | influenza virus cytokine storm age sex obesity |
url | https://www.mdpi.com/1999-4915/13/7/1362 |
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