Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies
Abstract Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In recent years, with an increase in extracellular vesicle (EV) research, the biogen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12964-020-00619-5 |
| _version_ | 1818189565061496832 |
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| author | Xueqiang Peng Liang Yang Yingbo Ma Yan Li Hangyu Li |
| author_facet | Xueqiang Peng Liang Yang Yingbo Ma Yan Li Hangyu Li |
| author_sort | Xueqiang Peng |
| collection | DOAJ |
| description | Abstract Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In recent years, with an increase in extracellular vesicle (EV) research, the biogenesis, fate, and pathological effects of MVBs have been increasingly studied. However, the mechanisms by which MVBs are sorted to the lysosome and plasma membrane remain unclear. In addition, whether the trafficking of MVBs can determine whether exosomes are released from cells, the factors are involved in cargo loading and regulating the fate of MVBs, and the roles that MVBs play in the development of disease are unknown. Consequently, this review focuses on the mechanism of MVB biogenesis, intraluminal vesicle formation, sorting of different cargoes, and regulation of their fate. We also discuss the mechanisms of emerging amphisome-dependent secretion and degradation. In addition, we highlight the contributions of MVBs to the heterogeneity of EVs, and their important roles in cancer. Thus, we attempt to unravel the various functions of MVBs in the cell and their multiple roles in tumor progression. Video Abstract |
| first_indexed | 2024-12-11T23:44:50Z |
| format | Article |
| id | doaj.art-84ee65a0f4ca4e8abddb7e9635be9702 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-11T23:44:50Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-84ee65a0f4ca4e8abddb7e9635be97022022-12-22T00:45:38ZengBMCCell Communication and Signaling1478-811X2020-08-0118111510.1186/s12964-020-00619-5Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodiesXueqiang Peng0Liang Yang1Yingbo Ma2Yan Li3Hangyu Li4Department of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityAbstract Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In recent years, with an increase in extracellular vesicle (EV) research, the biogenesis, fate, and pathological effects of MVBs have been increasingly studied. However, the mechanisms by which MVBs are sorted to the lysosome and plasma membrane remain unclear. In addition, whether the trafficking of MVBs can determine whether exosomes are released from cells, the factors are involved in cargo loading and regulating the fate of MVBs, and the roles that MVBs play in the development of disease are unknown. Consequently, this review focuses on the mechanism of MVB biogenesis, intraluminal vesicle formation, sorting of different cargoes, and regulation of their fate. We also discuss the mechanisms of emerging amphisome-dependent secretion and degradation. In addition, we highlight the contributions of MVBs to the heterogeneity of EVs, and their important roles in cancer. Thus, we attempt to unravel the various functions of MVBs in the cell and their multiple roles in tumor progression. Video Abstracthttp://link.springer.com/article/10.1186/s12964-020-00619-5Multivesicular bodyExtracellular vesiclesAmphisomeAutophagyTraffickingRelease |
| spellingShingle | Xueqiang Peng Liang Yang Yingbo Ma Yan Li Hangyu Li Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies Cell Communication and Signaling Multivesicular body Extracellular vesicles Amphisome Autophagy Trafficking Release |
| title | Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies |
| title_full | Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies |
| title_fullStr | Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies |
| title_full_unstemmed | Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies |
| title_short | Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies |
| title_sort | focus on the morphogenesis fate and the role in tumor progression of multivesicular bodies |
| topic | Multivesicular body Extracellular vesicles Amphisome Autophagy Trafficking Release |
| url | http://link.springer.com/article/10.1186/s12964-020-00619-5 |
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