Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine
Abstract Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM2.5) negatively impacts human health. Airways constitute a primary route of exposure but PM2.5‐contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15249 |
| _version_ | 1797387875370663936 |
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| author | Lena Ohlsson Christina Isaxon Sebastian Wrighton Wissal El Ouahidi Lisa Fornell Lena Uller Saema Ansar Ulrikke Voss |
| author_facet | Lena Ohlsson Christina Isaxon Sebastian Wrighton Wissal El Ouahidi Lisa Fornell Lena Uller Saema Ansar Ulrikke Voss |
| author_sort | Lena Ohlsson |
| collection | DOAJ |
| description | Abstract Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM2.5) negatively impacts human health. Airways constitute a primary route of exposure but PM2.5‐contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as well as enteric neuronal numbers after short‐ or long‐term exposure to urban PM2.5. Using a nebulizer, male rats were exposed to a mist with a concentration of 5.3mg PM2.5/m3 for 8 h (short term) or 1.8 mg PM2.5/m3 for 3 h/day, 5 days/week for 8 weeks (long‐term) with controls run in parallel. Samples were taken from three regions of the small intestine as well as the colon. Results showed that short‐term exposure to PM2.5 induces mucosal lesions and reduces IL1β levels in the small intestine but not colon. No significant changes were observed after long‐term exposure, suggesting the presence of intestinal adaptation to environmental stressors in the PM2.5. To our knowledge, this is the first study to systematically characterize regional effects along the intestine. |
| first_indexed | 2024-03-08T22:32:26Z |
| format | Article |
| id | doaj.art-84ef1f6b1ce249928d62d187fa8ca747 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T22:32:26Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-84ef1f6b1ce249928d62d187fa8ca7472023-12-18T02:20:41ZengWileyPhysiological Reports2051-817X2022-04-01107n/an/a10.14814/phy2.15249Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestineLena Ohlsson0Christina Isaxon1Sebastian Wrighton2Wissal El Ouahidi3Lisa Fornell4Lena Uller5Saema Ansar6Ulrikke Voss7Unit of Experimental Vascular Research Department of Clinical Sciences Lund University Lund SwedenDivision of Ergonomics and Aerosol Technology Department of Design Sciences Lund University Lund SwedenDivision of Infection Medicine Department of Clinical Sciences Lund University Lund SwedenUnit of Applied Neurovascular Research Department of Clinical Sciences Lund University Lund SwedenUnit of Applied Neurovascular Research Department of Clinical Sciences Lund University Lund SwedenUnit of Respiratory Immunopharmacology Department of Experimental Medical Sciences Lund University Lund SwedenUnit of Applied Neurovascular Research Department of Clinical Sciences Lund University Lund SwedenUnit of Applied Neurovascular Research Department of Clinical Sciences Lund University Lund SwedenAbstract Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM2.5) negatively impacts human health. Airways constitute a primary route of exposure but PM2.5‐contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as well as enteric neuronal numbers after short‐ or long‐term exposure to urban PM2.5. Using a nebulizer, male rats were exposed to a mist with a concentration of 5.3mg PM2.5/m3 for 8 h (short term) or 1.8 mg PM2.5/m3 for 3 h/day, 5 days/week for 8 weeks (long‐term) with controls run in parallel. Samples were taken from three regions of the small intestine as well as the colon. Results showed that short‐term exposure to PM2.5 induces mucosal lesions and reduces IL1β levels in the small intestine but not colon. No significant changes were observed after long‐term exposure, suggesting the presence of intestinal adaptation to environmental stressors in the PM2.5. To our knowledge, this is the first study to systematically characterize regional effects along the intestine.https://doi.org/10.14814/phy2.15249environmentalgastrointestinalinflammationphysiologytoxicologyurban air pollution |
| spellingShingle | Lena Ohlsson Christina Isaxon Sebastian Wrighton Wissal El Ouahidi Lisa Fornell Lena Uller Saema Ansar Ulrikke Voss Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine Physiological Reports environmental gastrointestinal inflammation physiology toxicology urban air pollution |
| title | Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine |
| title_full | Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine |
| title_fullStr | Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine |
| title_full_unstemmed | Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine |
| title_short | Short‐term exposure to urban PM2.5 particles induces histopathological and inflammatory changes in the rat small intestine |
| title_sort | short term exposure to urban pm2 5 particles induces histopathological and inflammatory changes in the rat small intestine |
| topic | environmental gastrointestinal inflammation physiology toxicology urban air pollution |
| url | https://doi.org/10.14814/phy2.15249 |
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