αvβ3 Integrin Expression and Mitogenic Effects by Thyroid Hormones in Chronic Lymphocytic Leukemia

αvβ3 Integrin Expression and Mitogenic Effects by Thyroid Hormones in Chronic Lymphocytic Leukemia

Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The thyroid hormones, T3 and T4, bind the αvβ3 integrin and activate phosphorylates ERK (pERK). These tumor-promoting actions were reported in a number of malignancies, but not in CLL. Methods: Primary cells from 22 CL...

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Bibliographic Details
Main Authors: Uri Abadi, Avivit Weisz, Dvora Kidron, Aviva Katzav, Aleck Hercbergs, Paul J. Davis, Martin H. Ellis, Osnat Ashur-Fabian
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Clinical Medicine
Subjects:
chronic lymphocytic leukemia
αvβ3 integrin
thyroid hormone
Online Access:https://www.mdpi.com/2077-0383/10/8/1766

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