Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol
The ‘Appelmans protocol’ is used by Eastern European researchers to generate therapeutic phages with novel lytic host ranges. Phage cocktails are iteratively grown on a suite of mostly refractory bacterial isolates until the evolved cocktail can lyse the phage-resistant strains....
Main Authors: | Ben H. Burrowes, Ian J. Molineux, Joe A. Fralick |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
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Series: | Viruses |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4915/11/3/241 |
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