Astaxanthin protects cognitive function of vascular dementia
Abstract Objective The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. Method VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12993-020-00172-8 |
| _version_ | 1818453560365416448 |
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| author | Ningwei Zhu Xiao Liang Ming Zhang Xiaolan Yin Hui Yang Yajun Zhi Guizhen Ying Jialing Zou Lei Chen Xiaokun Yao Hongwei Li |
| author_facet | Ningwei Zhu Xiao Liang Ming Zhang Xiaolan Yin Hui Yang Yajun Zhi Guizhen Ying Jialing Zou Lei Chen Xiaokun Yao Hongwei Li |
| author_sort | Ningwei Zhu |
| collection | DOAJ |
| description | Abstract Objective The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. Method VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Object recognition test and morris water maze test were used to evaluate cognitive function. Hematoxylin and eosin staining was performed to observe the hippocampal neuron structure. Enzyme-linked immunosorbent assay kit and bicinchoninic acid kit were respectively adopted to measure IL-1β and IL-4 protein expression and superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hippocampus and prefrontal cortex. Results AST improved the discrimination ability of VD mice. The escape latency and path length of VD mice treated with AST were dramatically reduced. Besides, AST 200 mg/kg enhanced crossing platform time and the number of times crossing the platform quadrant, and alleviated the morphological impairment in VD mice. Moreover, we found that AST inhibited IL-1β expression and MDA content, whereas promoted IL-4 expression and SOD activity in a dose-dependent manner. Conclusion AST could improve cognitive impairment and hippocampal neurons in VD mice, which may be related to suppression of inflammatory response and oxidative stress. |
| first_indexed | 2024-12-14T21:40:56Z |
| format | Article |
| id | doaj.art-84f44c95618749bdb6adc8a7a538ba35 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-14T21:40:56Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-84f44c95618749bdb6adc8a7a538ba352022-12-21T22:46:27ZengBMCBehavioral and Brain Functions1744-90812020-11-0116111010.1186/s12993-020-00172-8Astaxanthin protects cognitive function of vascular dementiaNingwei Zhu0Xiao Liang1Ming Zhang2Xiaolan Yin3Hui Yang4Yajun Zhi5Guizhen Ying6Jialing Zou7Lei Chen8Xiaokun Yao9Hongwei Li10Department of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical SciencesDepartment of PharmacyDepartment of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical SciencesDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeDepartment of Pharmacy, Zhejiang Pharmaceutical CollegeAbstract Objective The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. Method VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Object recognition test and morris water maze test were used to evaluate cognitive function. Hematoxylin and eosin staining was performed to observe the hippocampal neuron structure. Enzyme-linked immunosorbent assay kit and bicinchoninic acid kit were respectively adopted to measure IL-1β and IL-4 protein expression and superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hippocampus and prefrontal cortex. Results AST improved the discrimination ability of VD mice. The escape latency and path length of VD mice treated with AST were dramatically reduced. Besides, AST 200 mg/kg enhanced crossing platform time and the number of times crossing the platform quadrant, and alleviated the morphological impairment in VD mice. Moreover, we found that AST inhibited IL-1β expression and MDA content, whereas promoted IL-4 expression and SOD activity in a dose-dependent manner. Conclusion AST could improve cognitive impairment and hippocampal neurons in VD mice, which may be related to suppression of inflammatory response and oxidative stress.http://link.springer.com/article/10.1186/s12993-020-00172-8Vascular dementiaCognition functionAnti-inflammationAnti-oxidantAstaxanthin |
| spellingShingle | Ningwei Zhu Xiao Liang Ming Zhang Xiaolan Yin Hui Yang Yajun Zhi Guizhen Ying Jialing Zou Lei Chen Xiaokun Yao Hongwei Li Astaxanthin protects cognitive function of vascular dementia Behavioral and Brain Functions Vascular dementia Cognition function Anti-inflammation Anti-oxidant Astaxanthin |
| title | Astaxanthin protects cognitive function of vascular dementia |
| title_full | Astaxanthin protects cognitive function of vascular dementia |
| title_fullStr | Astaxanthin protects cognitive function of vascular dementia |
| title_full_unstemmed | Astaxanthin protects cognitive function of vascular dementia |
| title_short | Astaxanthin protects cognitive function of vascular dementia |
| title_sort | astaxanthin protects cognitive function of vascular dementia |
| topic | Vascular dementia Cognition function Anti-inflammation Anti-oxidant Astaxanthin |
| url | http://link.springer.com/article/10.1186/s12993-020-00172-8 |
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