The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism
Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, where fatty acid-derived metabolites, such as long chain fatty acyl-CoAs, a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00152/full |
| _version_ | 1811274286594260992 |
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| author | Tsutomu eTomita Kiminori eHosoda Junji eFujikura Nobuya eInagaki Kazuwa eNakao |
| author_facet | Tsutomu eTomita Kiminori eHosoda Junji eFujikura Nobuya eInagaki Kazuwa eNakao |
| author_sort | Tsutomu eTomita |
| collection | DOAJ |
| description | Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, where fatty acid-derived metabolites, such as long chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target. |
| first_indexed | 2024-04-12T23:16:16Z |
| format | Article |
| id | doaj.art-84f49816915049869df5de327226e7f7 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T23:16:16Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-84f49816915049869df5de327226e7f72022-12-22T03:12:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-09-01510.3389/fendo.2014.00152104897The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolismTsutomu eTomita0Kiminori eHosoda1Junji eFujikura2Nobuya eInagaki3Kazuwa eNakao4Kyoto University Graduate School of MedicineKyoto University Graduate School of MedicineKyoto University Graduate School of MedicineKyoto University Graduate School of MedicineKyoto University Graduate School of MedicineFree fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, where fatty acid-derived metabolites, such as long chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00152/fullinsulin secretionGPR40pancreatic beta cellsFFAR1LCFA |
| spellingShingle | Tsutomu eTomita Kiminori eHosoda Junji eFujikura Nobuya eInagaki Kazuwa eNakao The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism Frontiers in Endocrinology insulin secretion GPR40 pancreatic beta cells FFAR1 LCFA |
| title | The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism |
| title_full | The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism |
| title_fullStr | The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism |
| title_full_unstemmed | The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism |
| title_short | The G-protein-coupled long-chain fatty acid receptor GPR40 and glucose metabolism |
| title_sort | g protein coupled long chain fatty acid receptor gpr40 and glucose metabolism |
| topic | insulin secretion GPR40 pancreatic beta cells FFAR1 LCFA |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00152/full |
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