Differential antigen expression between human apocrine sweat glands and eccrine sweat glands
Bromhidrosis has a great negative impact on personal occupation and social psychology. It is not yet clear whether bromhidrosis is caused by apocrine sweat glands or the co-action of apocrine sweat glands and eccrine sweat glands. To distinguish between apocrine sweat glands and eccrine sweat gland...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-12-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | https://ejh.it/index.php/ejh/article/view/3559 |
| _version_ | 1797979111530954752 |
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| author | Manxiu Cao Lei Zhang Jiaqi Chen Cangyu Wang Junhong Zhao Xiang Liu Yongjing Yan Yue Tang Zixiu Chen Haihong Li |
| author_facet | Manxiu Cao Lei Zhang Jiaqi Chen Cangyu Wang Junhong Zhao Xiang Liu Yongjing Yan Yue Tang Zixiu Chen Haihong Li |
| author_sort | Manxiu Cao |
| collection | DOAJ |
| description |
Bromhidrosis has a great negative impact on personal occupation and social psychology. It is not yet clear whether bromhidrosis is caused by apocrine sweat glands or the co-action of apocrine sweat glands and eccrine sweat glands. To distinguish between apocrine sweat glands and eccrine sweat glands, specific antigen markers for apocrine sweat glands and eccrine sweat glands must be found first. In the study, we detected the expression of K7, K18, K19, Na+-K+-2Cl- cotransporter 1 (NKCC1), carbonic anhydrase II (CAII), Forkhead transcription factor a1 (Foxa1), homeobox transcription factor engrailed homeobox1 (En1), gross cystic disease fluid protein-15 (GCDFP-15), mucin-1 (MUC-1), cluster of differentiation 15 (CD15) and apolipoprotein (APOD) in eccrine sweat glands and apocrine sweat glands by immunofluorescence staining. The results showed that K7, K18, K19, Foxa1, GCDFP-15 and MUC-1 were expressed in both apocrine and eccrine sweat glands, CD15 and APOD were only expressed in apocrine sweat glands, and CAII, NKCC1 and En1 were only expressed in eccrine sweat glands. We conclude that CD15 and APOD can serve as specific markers for apocrine sweat glands, while CAII, NKCC1 and En1 can serve as specific markers for eccrine sweat glands to differentiate the two sweat glands.
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| first_indexed | 2024-04-11T05:34:51Z |
| format | Article |
| id | doaj.art-84f574794b2a4b30ad48980af867693d |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-04-11T05:34:51Z |
| publishDate | 2022-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-84f574794b2a4b30ad48980af867693d2022-12-22T14:52:45ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062022-12-0167110.4081/ejh.2023.3559Differential antigen expression between human apocrine sweat glands and eccrine sweat glandsManxiu Cao0Lei Zhang1Jiaqi Chen2Cangyu Wang3Junhong Zhao4Xiang Liu5Yongjing Yan6Yue Tang7Zixiu Chen8Haihong Li9Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Mental Health, Southern University of Science and Technology Hospital, Southern University of Science and Technology School of Medicine, Shenzhen, GuangdongDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, HubeiDepartment of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Bromhidrosis has a great negative impact on personal occupation and social psychology. It is not yet clear whether bromhidrosis is caused by apocrine sweat glands or the co-action of apocrine sweat glands and eccrine sweat glands. To distinguish between apocrine sweat glands and eccrine sweat glands, specific antigen markers for apocrine sweat glands and eccrine sweat glands must be found first. In the study, we detected the expression of K7, K18, K19, Na+-K+-2Cl- cotransporter 1 (NKCC1), carbonic anhydrase II (CAII), Forkhead transcription factor a1 (Foxa1), homeobox transcription factor engrailed homeobox1 (En1), gross cystic disease fluid protein-15 (GCDFP-15), mucin-1 (MUC-1), cluster of differentiation 15 (CD15) and apolipoprotein (APOD) in eccrine sweat glands and apocrine sweat glands by immunofluorescence staining. The results showed that K7, K18, K19, Foxa1, GCDFP-15 and MUC-1 were expressed in both apocrine and eccrine sweat glands, CD15 and APOD were only expressed in apocrine sweat glands, and CAII, NKCC1 and En1 were only expressed in eccrine sweat glands. We conclude that CD15 and APOD can serve as specific markers for apocrine sweat glands, while CAII, NKCC1 and En1 can serve as specific markers for eccrine sweat glands to differentiate the two sweat glands. https://ejh.it/index.php/ejh/article/view/3559apocrine sweat glands; eccrine sweat glands; human; differential markers; immunofluorescence |
| spellingShingle | Manxiu Cao Lei Zhang Jiaqi Chen Cangyu Wang Junhong Zhao Xiang Liu Yongjing Yan Yue Tang Zixiu Chen Haihong Li Differential antigen expression between human apocrine sweat glands and eccrine sweat glands European Journal of Histochemistry apocrine sweat glands; eccrine sweat glands; human; differential markers; immunofluorescence |
| title | Differential antigen expression between human apocrine sweat glands and eccrine sweat glands |
| title_full | Differential antigen expression between human apocrine sweat glands and eccrine sweat glands |
| title_fullStr | Differential antigen expression between human apocrine sweat glands and eccrine sweat glands |
| title_full_unstemmed | Differential antigen expression between human apocrine sweat glands and eccrine sweat glands |
| title_short | Differential antigen expression between human apocrine sweat glands and eccrine sweat glands |
| title_sort | differential antigen expression between human apocrine sweat glands and eccrine sweat glands |
| topic | apocrine sweat glands; eccrine sweat glands; human; differential markers; immunofluorescence |
| url | https://ejh.it/index.php/ejh/article/view/3559 |
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