The Crohn’s disease-related bacterial strain LF82 assembles biofilm-like communities to protect itself from phagolysosomal attack

Prudent et al. show that intracellular bacteria related to the Crohn’s disease, LF82, produce an extra-bacterial matrix that acts as a biofilm and controls the formation of LF82 intracellular bacterial communities. This study provides insights into the strategies that adherent invasive E. coli use t...

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Bibliographic Details
Main Authors: Victoria Prudent, Gaëlle Demarre, Emilie Vazeille, Maxime Wery, Nicole Quenech’Du, Antinéa Ravet, Julie Dauverd - Girault, Erwin van Dijk, Marie-Agnès Bringer, Marc Descrimes, Nicolas Barnich, Sylvie Rimsky, Antonin Morillon, Olivier Espéli
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02161-7
Description
Summary:Prudent et al. show that intracellular bacteria related to the Crohn’s disease, LF82, produce an extra-bacterial matrix that acts as a biofilm and controls the formation of LF82 intracellular bacterial communities. This study provides insights into the strategies that adherent invasive E. coli use to establish their replicative niche within macrophages.
ISSN:2399-3642