Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01057-7 |
| _version_ | 1818427393026555904 |
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| author | Rajeshwer S. Sankhala Ravi K. Lokareddy Salma Begum Ruth A. Pumroy Richard E. Gillilan Gino Cingolani |
| author_facet | Rajeshwer S. Sankhala Ravi K. Lokareddy Salma Begum Ruth A. Pumroy Richard E. Gillilan Gino Cingolani |
| author_sort | Rajeshwer S. Sankhala |
| collection | DOAJ |
| description | Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms. |
| first_indexed | 2024-12-14T14:45:00Z |
| format | Article |
| id | doaj.art-84f5d97d72034197ba5d8d902d0d44a1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:45:00Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-84f5d97d72034197ba5d8d902d0d44a12022-12-21T22:57:18ZengNature PortfolioNature Communications2041-17232017-10-018111510.1038/s41467-017-01057-7Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1Rajeshwer S. Sankhala0Ravi K. Lokareddy1Salma Begum2Ruth A. Pumroy3Richard E. Gillilan4Gino Cingolani5Department of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityMacromolecular Diffraction Facility, Cornell High Energy Synchrotron Source (MacCHESS), Cornell UniversityDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityImportin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.https://doi.org/10.1038/s41467-017-01057-7 |
| spellingShingle | Rajeshwer S. Sankhala Ravi K. Lokareddy Salma Begum Ruth A. Pumroy Richard E. Gillilan Gino Cingolani Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 Nature Communications |
| title | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 |
| title_full | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 |
| title_fullStr | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 |
| title_full_unstemmed | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 |
| title_short | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 |
| title_sort | three dimensional context rather than nls amino acid sequence determines importin α subtype specificity for rcc1 |
| url | https://doi.org/10.1038/s41467-017-01057-7 |
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