Concurrent Reactive Oxygen Species Generation and Aneuploidy Induction Contribute to Thymoquinone Anticancer Activity

Concurrent Reactive Oxygen Species Generation and Aneuploidy Induction Contribute to Thymoquinone Anticancer Activity

Thymoquinone (TQ) is the main biologically active constituent of <i>Nigella sativa</i>. Many studies have confirmed its anticancer actions. Herein, we investigated the different anticancer activities of, and considered resistance mechanisms to, TQ. MTT and clonogenic data showed TQ’s abi...

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Bibliographic Details
Main Authors: Mohammed Al-Hayali, Aimie Garces, Michael Stocks, Hilary Collins, Tracey D. Bradshaw
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
thymoquinone
aneuploidy
apoptosis
ROS generation
GSH depletion
Online Access:https://www.mdpi.com/1420-3049/26/17/5136

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