Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants
Sciatica characterized by irritation, inflammation, and compression of the lower back nerve, is considered one of the most common back ailments globally. Currently, the therapeutic regimens for sciatica are experiencing a paradigm shift from the conventional pharmacological approach toward exploring...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824000203 |
| _version_ | 1797322502029967360 |
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| author | Abdul Nasir Ome Kalsoom Afridi Sami Ullah Haroon Khan Qian Bai |
| author_facet | Abdul Nasir Ome Kalsoom Afridi Sami Ullah Haroon Khan Qian Bai |
| author_sort | Abdul Nasir |
| collection | DOAJ |
| description | Sciatica characterized by irritation, inflammation, and compression of the lower back nerve, is considered one of the most common back ailments globally. Currently, the therapeutic regimens for sciatica are experiencing a paradigm shift from the conventional pharmacological approach toward exploring potent phytochemicals from medicinal plants. There is a dire need to identify novel phytochemicals with anti-neuropathic potential. This review aimed to identify the potent phytochemicals from diverse medicinal plants capable of alleviating neuropathic pain associated with sciatica. This review describes the pathophysiology of sciatic nerve pain, its cellular mechanisms, and the pharmacological potential of various plants and phytochemicals using animal-based models of sciatic nerve injury-induced pain. Extensive searches across databases such as Medline, PubMed, Web of Science, Scopus, ScienceDirect, and Google Scholar were conducted. The findings highlights 39 families including Lamiaceae, Asteraceae, Fabaceae, and Apocyanaceae and Cucurbitaceae, effectively treating sciatic nerve injury-induced pain. Flavonoids made up 53% constituents, phenols and terpenoids made up 15%, alkaloids made up 13%, and glycosides made up 6% to be used in neuorpathic pain. Phytochemicals derived from various medicinal plants can serve as potential therapeutic targets for both acute and chronic sciatic injury-induced neuropathic pain. |
| first_indexed | 2024-03-08T05:14:15Z |
| format | Article |
| id | doaj.art-84f828a86ba1414480f4db62832463c4 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-08T05:14:15Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-84f828a86ba1414480f4db62832463c42024-02-07T04:42:30ZengElsevierPharmacological Research1096-11862024-02-01200107076Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plantsAbdul Nasir0Ome Kalsoom Afridi1Sami Ullah2Haroon Khan3Qian Bai4Department of Anesthesiology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Medical Research Center, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Biochemistry, Women University Swabi, PakistanDepartment of Biochemistry, Abdul Wali Khan University, Mardan, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Pakistan; Corresponding author.Department of Anesthesiology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Medical Research Center, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Correspondence to: Medical Research Center, The Second Affiliated Hospital of Zhengzhou University, 2 Jingba Rd, Zhengzhou 450000, Henan, China.Sciatica characterized by irritation, inflammation, and compression of the lower back nerve, is considered one of the most common back ailments globally. Currently, the therapeutic regimens for sciatica are experiencing a paradigm shift from the conventional pharmacological approach toward exploring potent phytochemicals from medicinal plants. There is a dire need to identify novel phytochemicals with anti-neuropathic potential. This review aimed to identify the potent phytochemicals from diverse medicinal plants capable of alleviating neuropathic pain associated with sciatica. This review describes the pathophysiology of sciatic nerve pain, its cellular mechanisms, and the pharmacological potential of various plants and phytochemicals using animal-based models of sciatic nerve injury-induced pain. Extensive searches across databases such as Medline, PubMed, Web of Science, Scopus, ScienceDirect, and Google Scholar were conducted. The findings highlights 39 families including Lamiaceae, Asteraceae, Fabaceae, and Apocyanaceae and Cucurbitaceae, effectively treating sciatic nerve injury-induced pain. Flavonoids made up 53% constituents, phenols and terpenoids made up 15%, alkaloids made up 13%, and glycosides made up 6% to be used in neuorpathic pain. Phytochemicals derived from various medicinal plants can serve as potential therapeutic targets for both acute and chronic sciatic injury-induced neuropathic pain.http://www.sciencedirect.com/science/article/pii/S1043661824000203Sciatica painMedicinal plantsPhytoconstituentsMechanisms of actionPrevalence |
| spellingShingle | Abdul Nasir Ome Kalsoom Afridi Sami Ullah Haroon Khan Qian Bai Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants Pharmacological Research Sciatica pain Medicinal plants Phytoconstituents Mechanisms of action Prevalence |
| title | Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants |
| title_full | Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants |
| title_fullStr | Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants |
| title_full_unstemmed | Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants |
| title_short | Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants |
| title_sort | mitigation of sciatica injury induced neuropathic pain through active metabolites derived from medicinal plants |
| topic | Sciatica pain Medicinal plants Phytoconstituents Mechanisms of action Prevalence |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824000203 |
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