Osteopontin Regulates Ubiquitin-Dependent Degradation of Stat1 in Murine Mammary Epithelial Tumor Cells

Osteopontin Regulates Ubiquitin-Dependent Degradation of Stat1 in Murine Mammary Epithelial Tumor Cells

Background: Osteopontin (OPN) is a secreted glycoprotein that mediates cell-matrix interactions and cellular signaling by binding with integrin (primarily αvβ3) and CD44 receptors. OPN regulates cell adhesion, chemotaxis, macrophage-directed IL-10 suppression, stressdependent angiogenesis, apoptosis...

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Bibliographic Details
Main Authors: Chengjiang Gao, Zhiyong Mi, Hongtao Guo, Paul C. Kuo
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ubiquitin
SLIM
proteasome
p21
interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800297

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