Study on detection of insulin autoimmune antibodies: limitation and countermeasures
Insulin autoimmune antibodies (IAA) detection are commonly applied to diagnosis of type 1 diabetes mellitus(T1DM), prediction of incidence risk and disease outcomes. It can also be used for the diagnosis of insulin autoimmune syndrome (IAS) and exogenous insulin antibodies syndrome (EIAS). The probl...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Diagnostics Concepts & Practice
2022-02-01
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| Series: | Zhenduanxue lilun yu shijian |
| Subjects: | |
| Online Access: | http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1654733780247-1820615736.pdf |
| _version_ | 1797975530419519488 |
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| author | CHEN Xuyang, GU Weiqiong |
| author_facet | CHEN Xuyang, GU Weiqiong |
| author_sort | CHEN Xuyang, GU Weiqiong |
| collection | DOAJ |
| description | Insulin autoimmune antibodies (IAA) detection are commonly applied to diagnosis of type 1 diabetes mellitus(T1DM), prediction of incidence risk and disease outcomes. It can also be used for the diagnosis of insulin autoimmune syndrome (IAS) and exogenous insulin antibodies syndrome (EIAS). The problem is that IAA has different subtypes which may lead to uncertainties in the prediction and diagnosis of T1DM since the existing clinical detection technology is limited to subdivide them. Meanwhile, the diabetes complicated with IAS or T1DM complicated with EIAS bring more difficulty in detecting IAA subtype as differentiating endogenous etiology(T1DM and IAS) from exogenous etiology (EIAS). In recent years, the studies on IAA affinity, isotype and antigenic epitope may enable laboratory detection to classify IAA groups, which is worth paying attention to. |
| first_indexed | 2024-04-11T04:37:00Z |
| format | Article |
| id | doaj.art-84f90c4cb2a44d2191da2586df5c90c6 |
| institution | Directory Open Access Journal |
| issn | 1671-2870 |
| language | zho |
| last_indexed | 2024-04-11T04:37:00Z |
| publishDate | 2022-02-01 |
| publisher | Editorial Office of Journal of Diagnostics Concepts & Practice |
| record_format | Article |
| series | Zhenduanxue lilun yu shijian |
| spelling | doaj.art-84f90c4cb2a44d2191da2586df5c90c62022-12-28T09:19:52ZzhoEditorial Office of Journal of Diagnostics Concepts & PracticeZhenduanxue lilun yu shijian1671-28702022-02-012101959810.16150/j.1671-2870.2022.01.018Study on detection of insulin autoimmune antibodies: limitation and countermeasuresCHEN Xuyang, GU Weiqiong0Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Institute of Endocrine and Metabolic Diseases; National Clinical Research Center for Metabolic Diseases, Shanghai 200025 ChinaInsulin autoimmune antibodies (IAA) detection are commonly applied to diagnosis of type 1 diabetes mellitus(T1DM), prediction of incidence risk and disease outcomes. It can also be used for the diagnosis of insulin autoimmune syndrome (IAS) and exogenous insulin antibodies syndrome (EIAS). The problem is that IAA has different subtypes which may lead to uncertainties in the prediction and diagnosis of T1DM since the existing clinical detection technology is limited to subdivide them. Meanwhile, the diabetes complicated with IAS or T1DM complicated with EIAS bring more difficulty in detecting IAA subtype as differentiating endogenous etiology(T1DM and IAS) from exogenous etiology (EIAS). In recent years, the studies on IAA affinity, isotype and antigenic epitope may enable laboratory detection to classify IAA groups, which is worth paying attention to.http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1654733780247-1820615736.pdf|type 1 diabetes|insulin antibodies|insulin autoimmunity syndrome|exogenous insulin antibody positive syndrome |
| spellingShingle | CHEN Xuyang, GU Weiqiong Study on detection of insulin autoimmune antibodies: limitation and countermeasures Zhenduanxue lilun yu shijian |type 1 diabetes|insulin antibodies|insulin autoimmunity syndrome|exogenous insulin antibody positive syndrome |
| title | Study on detection of insulin autoimmune antibodies: limitation and countermeasures |
| title_full | Study on detection of insulin autoimmune antibodies: limitation and countermeasures |
| title_fullStr | Study on detection of insulin autoimmune antibodies: limitation and countermeasures |
| title_full_unstemmed | Study on detection of insulin autoimmune antibodies: limitation and countermeasures |
| title_short | Study on detection of insulin autoimmune antibodies: limitation and countermeasures |
| title_sort | study on detection of insulin autoimmune antibodies limitation and countermeasures |
| topic | |type 1 diabetes|insulin antibodies|insulin autoimmunity syndrome|exogenous insulin antibody positive syndrome |
| url | http://www.qk.sjtu.edu.cn/jdcp/fileup/1671-2870/PDF/1654733780247-1820615736.pdf |
| work_keys_str_mv | AT chenxuyangguweiqiong studyondetectionofinsulinautoimmuneantibodieslimitationandcountermeasures |