On the origin of tremor in Parkinson's disease.
The exact origin of tremor in Parkinson's disease remains unknown. We explain why the existing data converge on the basal ganglia-thalamo-cortical loop as a tremor generator and consider a conductance-based model of subthalamo-pallidal circuits embedded into a simplified representation of the b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848541/pdf/?tool=EBI |
| _version_ | 1818700866876604416 |
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| author | Andrey Dovzhenok Leonid L Rubchinsky |
| author_facet | Andrey Dovzhenok Leonid L Rubchinsky |
| author_sort | Andrey Dovzhenok |
| collection | DOAJ |
| description | The exact origin of tremor in Parkinson's disease remains unknown. We explain why the existing data converge on the basal ganglia-thalamo-cortical loop as a tremor generator and consider a conductance-based model of subthalamo-pallidal circuits embedded into a simplified representation of the basal ganglia-thalamo-cortical circuit to investigate the dynamics of this loop. We show how variation of the strength of dopamine-modulated connections in the basal ganglia-thalamo-cortical loop (representing the decreasing dopamine level in Parkinson's disease) leads to the occurrence of tremor-like burst firing. These tremor-like oscillations are suppressed when the connections are modulated back to represent a higher dopamine level (as it would be the case in dopaminergic therapy), as well as when the basal ganglia-thalamo-cortical loop is broken (as would be the case for ablative anti-parkinsonian surgeries). Thus, the proposed model provides an explanation for the basal ganglia-thalamo-cortical loop mechanism of tremor generation. The strengthening of the loop leads to tremor oscillations, while the weakening or disconnection of the loop suppresses them. The loop origin of parkinsonian tremor also suggests that new tremor-suppression therapies may have anatomical targets in different cortical and subcortical areas as long as they are within the basal ganglia-thalamo-cortical loop. |
| first_indexed | 2024-12-17T15:11:45Z |
| format | Article |
| id | doaj.art-84fa6cfaa212467cb44c4501a85bcb73 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:11:45Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-84fa6cfaa212467cb44c4501a85bcb732022-12-21T21:43:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4159810.1371/journal.pone.0041598On the origin of tremor in Parkinson's disease.Andrey DovzhenokLeonid L RubchinskyThe exact origin of tremor in Parkinson's disease remains unknown. We explain why the existing data converge on the basal ganglia-thalamo-cortical loop as a tremor generator and consider a conductance-based model of subthalamo-pallidal circuits embedded into a simplified representation of the basal ganglia-thalamo-cortical circuit to investigate the dynamics of this loop. We show how variation of the strength of dopamine-modulated connections in the basal ganglia-thalamo-cortical loop (representing the decreasing dopamine level in Parkinson's disease) leads to the occurrence of tremor-like burst firing. These tremor-like oscillations are suppressed when the connections are modulated back to represent a higher dopamine level (as it would be the case in dopaminergic therapy), as well as when the basal ganglia-thalamo-cortical loop is broken (as would be the case for ablative anti-parkinsonian surgeries). Thus, the proposed model provides an explanation for the basal ganglia-thalamo-cortical loop mechanism of tremor generation. The strengthening of the loop leads to tremor oscillations, while the weakening or disconnection of the loop suppresses them. The loop origin of parkinsonian tremor also suggests that new tremor-suppression therapies may have anatomical targets in different cortical and subcortical areas as long as they are within the basal ganglia-thalamo-cortical loop.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848541/pdf/?tool=EBI |
| spellingShingle | Andrey Dovzhenok Leonid L Rubchinsky On the origin of tremor in Parkinson's disease. PLoS ONE |
| title | On the origin of tremor in Parkinson's disease. |
| title_full | On the origin of tremor in Parkinson's disease. |
| title_fullStr | On the origin of tremor in Parkinson's disease. |
| title_full_unstemmed | On the origin of tremor in Parkinson's disease. |
| title_short | On the origin of tremor in Parkinson's disease. |
| title_sort | on the origin of tremor in parkinson s disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848541/pdf/?tool=EBI |
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