The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder
ABSTRACTCircadian rhythm regulates physiological cycles of awareness and sleepiness. Melatonin production is primarily regulated by circadian regulation of gene expression and is involved in sleep homeostasis. If the circadian rhythm is abnormal, sleep disorders, such as insomnia and several other d...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2023.2180535 |
| _version_ | 1797361645436010496 |
|---|---|
| author | Ji Young Kim Wanil Kim Kyung-Ha Lee |
| author_facet | Ji Young Kim Wanil Kim Kyung-Ha Lee |
| author_sort | Ji Young Kim |
| collection | DOAJ |
| description | ABSTRACTCircadian rhythm regulates physiological cycles of awareness and sleepiness. Melatonin production is primarily regulated by circadian regulation of gene expression and is involved in sleep homeostasis. If the circadian rhythm is abnormal, sleep disorders, such as insomnia and several other diseases, can occur. The term ‘autism spectrum disorder (ASD)’ is used to characterize people who exhibit a certain set of repetitive behaviors, severely constrained interests, social deficits, and/or sensory behaviors that start very early in life. Because many patients with ASD suffer from sleep disorders, sleep disorders and melatonin dysregulation are attracting attention for their potential roles in ASD. ASD is caused by abnormalities during the neurodevelopmental processes owing to various genetic or environmental factors. Recently, the role of microRNAs (miRNAs) in circadian rhythm and ASD have gained attraction. We hypothesized that the relationship between circadian rhythm and ASD could be explained by miRNAs that can regulate or be regulated by either or both. In this study, we introduced a possible molecular link between circadian rhythm and ASD. We performed a thorough literature review to understand their complexity. |
| first_indexed | 2024-03-08T15:57:40Z |
| format | Article |
| id | doaj.art-84fad907c7794eb6b85dd4937d58c341 |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-03-08T15:57:40Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-84fad907c7794eb6b85dd4937d58c3412024-01-08T17:12:29ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852023-12-01271385210.1080/19768354.2023.2180535The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorderJi Young Kim0Wanil Kim1Kyung-Ha Lee2Department of Molecular Biology, Pusan National University, Busan, Republic of KoreaDepartment of Biochemistry, College of Medicine, Gyeongsang National University, Jinju-si, Republic of KoreaDepartment of Molecular Biology, Pusan National University, Busan, Republic of KoreaABSTRACTCircadian rhythm regulates physiological cycles of awareness and sleepiness. Melatonin production is primarily regulated by circadian regulation of gene expression and is involved in sleep homeostasis. If the circadian rhythm is abnormal, sleep disorders, such as insomnia and several other diseases, can occur. The term ‘autism spectrum disorder (ASD)’ is used to characterize people who exhibit a certain set of repetitive behaviors, severely constrained interests, social deficits, and/or sensory behaviors that start very early in life. Because many patients with ASD suffer from sleep disorders, sleep disorders and melatonin dysregulation are attracting attention for their potential roles in ASD. ASD is caused by abnormalities during the neurodevelopmental processes owing to various genetic or environmental factors. Recently, the role of microRNAs (miRNAs) in circadian rhythm and ASD have gained attraction. We hypothesized that the relationship between circadian rhythm and ASD could be explained by miRNAs that can regulate or be regulated by either or both. In this study, we introduced a possible molecular link between circadian rhythm and ASD. We performed a thorough literature review to understand their complexity.https://www.tandfonline.com/doi/10.1080/19768354.2023.2180535Circadian rhythmMicroRNAautism spectrum disorder |
| spellingShingle | Ji Young Kim Wanil Kim Kyung-Ha Lee The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder Animal Cells and Systems Circadian rhythm MicroRNA autism spectrum disorder |
| title | The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder |
| title_full | The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder |
| title_fullStr | The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder |
| title_full_unstemmed | The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder |
| title_short | The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder |
| title_sort | role of micrornas in the molecular link between circadian rhythm and autism spectrum disorder |
| topic | Circadian rhythm MicroRNA autism spectrum disorder |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2023.2180535 |
| work_keys_str_mv | AT jiyoungkim theroleofmicrornasinthemolecularlinkbetweencircadianrhythmandautismspectrumdisorder AT wanilkim theroleofmicrornasinthemolecularlinkbetweencircadianrhythmandautismspectrumdisorder AT kyunghalee theroleofmicrornasinthemolecularlinkbetweencircadianrhythmandautismspectrumdisorder AT jiyoungkim roleofmicrornasinthemolecularlinkbetweencircadianrhythmandautismspectrumdisorder AT wanilkim roleofmicrornasinthemolecularlinkbetweencircadianrhythmandautismspectrumdisorder AT kyunghalee roleofmicrornasinthemolecularlinkbetweencircadianrhythmandautismspectrumdisorder |