Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer
Immune checkpoint blockade (ICB) therapy has evolved as a revolutionized therapeutic modality to eradicate tumor cells by releasing the brake of the antitumor immune response. However, only a subset of patients could benefit from ICB treatment currently. Phototherapy usually includes photothermal th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.955920/full |
| _version_ | 1811187659298570240 |
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| author | Yujie Zhao Xu Liu Xu Liu Xinyu Liu Jing Yu Xin Bai Xi Wu Xinyu Guo Zhihui Liu Xiaowei Liu |
| author_facet | Yujie Zhao Xu Liu Xu Liu Xinyu Liu Jing Yu Xin Bai Xi Wu Xinyu Guo Zhihui Liu Xiaowei Liu |
| author_sort | Yujie Zhao |
| collection | DOAJ |
| description | Immune checkpoint blockade (ICB) therapy has evolved as a revolutionized therapeutic modality to eradicate tumor cells by releasing the brake of the antitumor immune response. However, only a subset of patients could benefit from ICB treatment currently. Phototherapy usually includes photothermal therapy (PTT) and photodynamic therapy (PDT). PTT exerts a local therapeutic effect by using photothermal agents to generate heat upon laser irradiation. PDT utilizes irradiated photosensitizers with a laser to produce reactive oxygen species to kill the target cells. Both PTT and PDT can induce immunogenic cell death in tumors to activate antigen-presenting cells and promote T cell infiltration. Therefore, combining ICB treatment with PTT/PDT can enhance the antitumor immune response and prevent tumor metastases and recurrence. In this review, we summarized the mechanism of phototherapy in cancer immunotherapy and discussed the recent advances in the development of phototherapy combined with ICB therapy to treat malignant tumors. Moreover, we also outlined the significant progress of phototherapy combined with targeted therapy or chemotherapy to improve ICB in preclinical and clinical studies. Finally, we analyzed the current challenges of this novel combination treatment regimen. We believe that the next-generation technology breakthrough in cancer treatment may come from this combinational win-win strategy of photoimmunotherapy. |
| first_indexed | 2024-04-11T14:05:57Z |
| format | Article |
| id | doaj.art-84fb909e7c644d3c9f878b3e5c0d3d95 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T14:05:57Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-84fb909e7c644d3c9f878b3e5c0d3d952022-12-22T04:19:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.955920955920Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancerYujie Zhao0Xu Liu1Xu Liu2Xinyu Liu3Jing Yu4Xin Bai5Xi Wu6Xinyu Guo7Zhihui Liu8Xiaowei Liu9Laboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Head, Neck and Mammary Gland Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaImmune checkpoint blockade (ICB) therapy has evolved as a revolutionized therapeutic modality to eradicate tumor cells by releasing the brake of the antitumor immune response. However, only a subset of patients could benefit from ICB treatment currently. Phototherapy usually includes photothermal therapy (PTT) and photodynamic therapy (PDT). PTT exerts a local therapeutic effect by using photothermal agents to generate heat upon laser irradiation. PDT utilizes irradiated photosensitizers with a laser to produce reactive oxygen species to kill the target cells. Both PTT and PDT can induce immunogenic cell death in tumors to activate antigen-presenting cells and promote T cell infiltration. Therefore, combining ICB treatment with PTT/PDT can enhance the antitumor immune response and prevent tumor metastases and recurrence. In this review, we summarized the mechanism of phototherapy in cancer immunotherapy and discussed the recent advances in the development of phototherapy combined with ICB therapy to treat malignant tumors. Moreover, we also outlined the significant progress of phototherapy combined with targeted therapy or chemotherapy to improve ICB in preclinical and clinical studies. Finally, we analyzed the current challenges of this novel combination treatment regimen. We believe that the next-generation technology breakthrough in cancer treatment may come from this combinational win-win strategy of photoimmunotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2022.955920/fullimmune checkpoint blockadephotothermal therapy (PTT)photodynamic therapy (PDT)immunogenic cell death (ICD)tumor-infiltrating T cellsnanoparticles |
| spellingShingle | Yujie Zhao Xu Liu Xu Liu Xinyu Liu Jing Yu Xin Bai Xi Wu Xinyu Guo Zhihui Liu Xiaowei Liu Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer Frontiers in Immunology immune checkpoint blockade photothermal therapy (PTT) photodynamic therapy (PDT) immunogenic cell death (ICD) tumor-infiltrating T cells nanoparticles |
| title | Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer |
| title_full | Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer |
| title_fullStr | Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer |
| title_full_unstemmed | Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer |
| title_short | Combination of phototherapy with immune checkpoint blockade: Theory and practice in cancer |
| title_sort | combination of phototherapy with immune checkpoint blockade theory and practice in cancer |
| topic | immune checkpoint blockade photothermal therapy (PTT) photodynamic therapy (PDT) immunogenic cell death (ICD) tumor-infiltrating T cells nanoparticles |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.955920/full |
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