Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
In the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). Here, the authors show that Drosophila EG are polarized cells that form an internal diffusion barrier. EG cell polarity requires βHeavy-Spec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26462-x |
| _version_ | 1818754537039593472 |
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| author | Nicole Pogodalla Holger Kranenburg Simone Rey Silke Rodrigues Albert Cardona Christian Klämbt |
| author_facet | Nicole Pogodalla Holger Kranenburg Simone Rey Silke Rodrigues Albert Cardona Christian Klämbt |
| author_sort | Nicole Pogodalla |
| collection | DOAJ |
| description | In the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). Here, the authors show that Drosophila EG are polarized cells that form an internal diffusion barrier. EG cell polarity requires βHeavy-Spectrin and is needed for normal locomotor behaviour. |
| first_indexed | 2024-12-18T05:24:49Z |
| format | Article |
| id | doaj.art-84fcc40bb7aa433c9ea9394660da7944 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:24:49Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-84fcc40bb7aa433c9ea9394660da79442022-12-21T21:19:33ZengNature PortfolioNature Communications2041-17232021-11-0112111810.1038/s41467-021-26462-xDrosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropilNicole Pogodalla0Holger Kranenburg1Simone Rey2Silke Rodrigues3Albert Cardona4Christian Klämbt5Institut für Neuro- und Verhaltensbiologie, Universität MünsterInstitut für Neuro- und Verhaltensbiologie, Universität MünsterInstitut für Neuro- und Verhaltensbiologie, Universität MünsterInstitut für Neuro- und Verhaltensbiologie, Universität MünsterCambridge Biomedical CampusInstitut für Neuro- und Verhaltensbiologie, Universität MünsterIn the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). Here, the authors show that Drosophila EG are polarized cells that form an internal diffusion barrier. EG cell polarity requires βHeavy-Spectrin and is needed for normal locomotor behaviour.https://doi.org/10.1038/s41467-021-26462-x |
| spellingShingle | Nicole Pogodalla Holger Kranenburg Simone Rey Silke Rodrigues Albert Cardona Christian Klämbt Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil Nature Communications |
| title | Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil |
| title_full | Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil |
| title_fullStr | Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil |
| title_full_unstemmed | Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil |
| title_short | Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil |
| title_sort | drosophila ssheavy spectrin is required in polarized ensheathing glia that form a diffusion barrier around the neuropil |
| url | https://doi.org/10.1038/s41467-021-26462-x |
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