The curious case of Gαs gain-of-function in neoplasia

The curious case of Gαs gain-of-function in neoplasia

Abstract Background Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in spec...

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Bibliographic Details
Main Authors: Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi, Claudio Bassi
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Cancer
Subjects:
GNAS
Heterotrimeric Gs protein
Activating mutation
Neoplasm
McCune Albright Syndrome
Intraductal papillary mucinous neoplasm
Online Access:http://link.springer.com/article/10.1186/s12885-018-4133-z

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