The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single infectious entity and its causative agent, <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), has been able to evolve resistance to all existing drugs in the treatment arsenal complicating dis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/2/211 |
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| author | Helena I. Boshoff Neha Malhotra Clifton E. Barry Sangmi Oh |
| author_facet | Helena I. Boshoff Neha Malhotra Clifton E. Barry Sangmi Oh |
| author_sort | Helena I. Boshoff |
| collection | DOAJ |
| description | Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single infectious entity and its causative agent, <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), has been able to evolve resistance to all existing drugs in the treatment arsenal complicating disease management programs. In drug discovery efforts, natural products are important starting points in generating novel scaffolds that have evolved to specifically bind to vulnerable targets not only in pathogens such as <i>Mtb</i>, but also in mammalian targets associated with human diseases. Structural diversity is one of the most attractive features of natural products. This review provides a summary of fused-nitrogen-containing heterocycles found in the natural products reported in the literature that are known to have antitubercular activities. The structurally targeted natural products discussed in this review could provide a revealing insight into novel chemical aspects with novel biological functions for TB drug discovery efforts. |
| first_indexed | 2024-03-07T22:18:02Z |
| format | Article |
| id | doaj.art-85007ad3f4864bfd8ade6f5af64aa29c |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-07T22:18:02Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-85007ad3f4864bfd8ade6f5af64aa29c2024-02-23T15:30:42ZengMDPI AGPharmaceuticals1424-82472024-02-0117221110.3390/ph17020211The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing HeterocyclesHelena I. Boshoff0Neha Malhotra1Clifton E. Barry2Sangmi Oh3Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USATuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USATuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USATuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USATuberculosis (TB) is notorious as the leading cause of death worldwide due to a single infectious entity and its causative agent, <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), has been able to evolve resistance to all existing drugs in the treatment arsenal complicating disease management programs. In drug discovery efforts, natural products are important starting points in generating novel scaffolds that have evolved to specifically bind to vulnerable targets not only in pathogens such as <i>Mtb</i>, but also in mammalian targets associated with human diseases. Structural diversity is one of the most attractive features of natural products. This review provides a summary of fused-nitrogen-containing heterocycles found in the natural products reported in the literature that are known to have antitubercular activities. The structurally targeted natural products discussed in this review could provide a revealing insight into novel chemical aspects with novel biological functions for TB drug discovery efforts.https://www.mdpi.com/1424-8247/17/2/211tuberculosismycobacterianatural productsheterocyclesantitubercular activityantibiotics |
| spellingShingle | Helena I. Boshoff Neha Malhotra Clifton E. Barry Sangmi Oh The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles Pharmaceuticals tuberculosis mycobacteria natural products heterocycles antitubercular activity antibiotics |
| title | The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles |
| title_full | The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles |
| title_fullStr | The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles |
| title_full_unstemmed | The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles |
| title_short | The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles |
| title_sort | antitubercular activities of natural products with fused nitrogen containing heterocycles |
| topic | tuberculosis mycobacteria natural products heterocycles antitubercular activity antibiotics |
| url | https://www.mdpi.com/1424-8247/17/2/211 |
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