The over expression of thioredoxin during malignancies
Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells. The efficacy of thioredoxin system has been represented in a wide range of physiological and...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2014-09-01
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| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | http://rcm.mums.ac.ir/pdf_3167_cd4d36d053a21b7c16d289259d8c4e5a.html |
| _version_ | 1811193046736306176 |
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| author | Shahaboddin Shabani Navid Nourizadeh Mohammadsaleh Soltankhah |
| author_facet | Shahaboddin Shabani Navid Nourizadeh Mohammadsaleh Soltankhah |
| author_sort | Shahaboddin Shabani |
| collection | DOAJ |
| description | Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells. The efficacy of thioredoxin system has been represented in a wide range of physiological and biological reactions in bacteria, yeast, plants, mammals and etc. including DNA synthesis, regulation of transcription factors, protein repairing, regulating the photosynthesis and controlling the apoptosis and preventing oxidative stresses, filamentous phage assembly, immune-modulating, neuronal survival, pregnancy and birth and many other physiological and biological functions. The up-regulation of thioredoxin has been observed in various malignancies, which was associated with tumor angiogenesis and development. In this regard, the thiordoxin system has become a putative target in new chemotherapeutic methods. In this study, we mentioned various features of thioredoxin system in malignant cells and reviewed the articles which have evaluated the expression rate of thioredoxin system in malignancies. |
| first_indexed | 2024-04-12T00:01:53Z |
| format | Article |
| id | doaj.art-85016b0210f44cceb66ac929e22706bc |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-12T00:01:53Z |
| publishDate | 2014-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-85016b0210f44cceb66ac929e22706bc2022-12-22T03:56:12ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922014-09-01142182243167The over expression of thioredoxin during malignanciesShahaboddin Shabani0Navid Nourizadeh1Mohammadsaleh Soltankhah2Department of otorhinolaryngology - head and neck surgery, Mashhad University of Medical Sciences, Mashhad, IranDepartment of otorhinolaryngology - head and neck surgery, Mashhad University of Medical Sciences, Mashhad, IranDepartment of otorhinolaryngology - head and neck surgery, Mashhad University of Medical Sciences, Mashhad, IranThioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells. The efficacy of thioredoxin system has been represented in a wide range of physiological and biological reactions in bacteria, yeast, plants, mammals and etc. including DNA synthesis, regulation of transcription factors, protein repairing, regulating the photosynthesis and controlling the apoptosis and preventing oxidative stresses, filamentous phage assembly, immune-modulating, neuronal survival, pregnancy and birth and many other physiological and biological functions. The up-regulation of thioredoxin has been observed in various malignancies, which was associated with tumor angiogenesis and development. In this regard, the thiordoxin system has become a putative target in new chemotherapeutic methods. In this study, we mentioned various features of thioredoxin system in malignant cells and reviewed the articles which have evaluated the expression rate of thioredoxin system in malignancies.http://rcm.mums.ac.ir/pdf_3167_cd4d36d053a21b7c16d289259d8c4e5a.htmlMalignancyThioredoxinThioredoxin reductaseThioredoxin system |
| spellingShingle | Shahaboddin Shabani Navid Nourizadeh Mohammadsaleh Soltankhah The over expression of thioredoxin during malignancies Reviews in Clinical Medicine Malignancy Thioredoxin Thioredoxin reductase Thioredoxin system |
| title | The over expression of thioredoxin during malignancies |
| title_full | The over expression of thioredoxin during malignancies |
| title_fullStr | The over expression of thioredoxin during malignancies |
| title_full_unstemmed | The over expression of thioredoxin during malignancies |
| title_short | The over expression of thioredoxin during malignancies |
| title_sort | over expression of thioredoxin during malignancies |
| topic | Malignancy Thioredoxin Thioredoxin reductase Thioredoxin system |
| url | http://rcm.mums.ac.ir/pdf_3167_cd4d36d053a21b7c16d289259d8c4e5a.html |
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