The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats
Background: Exercise training can be effective on cardiac physiological hypertrophy (that is favorable for cardiac function) by changing the concentration of growth factors and their receptors. The aim of this study was to determine the effects of eight weeks of resistance training on activin recept...
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| Format: | Article |
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Isfahan University of Medical Sciences
2019-01-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/10576 |
| _version_ | 1797711866367049728 |
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| author | Behnam Masoudian Akbar Azamian-Jazi Mohammad Faramarzi Ardeshir Talebi |
| author_facet | Behnam Masoudian Akbar Azamian-Jazi Mohammad Faramarzi Ardeshir Talebi |
| author_sort | Behnam Masoudian |
| collection | DOAJ |
| description | Background: Exercise training can be effective on cardiac physiological hypertrophy (that is favorable for cardiac function) by changing the concentration of growth factors and their receptors. The aim of this study was to determine the effects of eight weeks of resistance training on activin receptor type II-B (ActRIIβ), as well as plasma levels of growth differentiation factor 11 (GDF11) and growth differentiation factor 8 (GDF8) in cardiac physiological hypertrophy in male Wistar rats.
Methods: After the familiarization period, fourteen 3-month-old male Wistar rats were randomly divided into control and training groups (n= 7). Resistance training included 8 weeks and 5 sessions per week climbing from a 1-meter ladder. GDF11 and GDF8 of plasma were measured using enzyme-linked immunosorbent assay (ELISA) method, and ActRIIB of left ventricular myocardium was measured using immunohistochemistry (IHC) method. Data were analyzed using independent t test and Mann-Whitney U at the significance level of P < 0.050.
Findings: There was a significant difference between the training and control groups in heart weight (P = 0.004), heart weight/body weight (P =0.045), GDF11 (P = 0.001), and GDF8/GDF11 (P = 0.015). There was not any significant differences between the training and control groups in ActRIIβ (P = 0.768) and GDF8 (P = 0.295) levels.
Conclusion: According to the results of the present study, it seems that resistance training with favorable effects on growth factors is an important strategy in cardiac physiological hypertrophy. |
| first_indexed | 2024-03-12T07:13:26Z |
| format | Article |
| id | doaj.art-8505c02c8c724c75a6b41113b7427fca |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T07:13:26Z |
| publishDate | 2019-01-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-8505c02c8c724c75a6b41113b7427fca2023-09-02T22:57:13ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-01-01365021308131310.22122/jims.v36i502.105763247The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar RatsBehnam Masoudian0Akbar Azamian-Jazi1Mohammad Faramarzi2Ardeshir Talebi3PhD Student, Department of Sport Sciences, School of Literature and Humanities, Shahrekord University, Shahrekord, IranAssociate Professor, Department of Sport Sciences, School of Literature and Humanities, Shahrekord University, Shahrekord, IranAssociate Professor, Department of Sport Sciences, School of Literature and Humanities, Shahrekord University, Shahrekord, IranAssociate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Exercise training can be effective on cardiac physiological hypertrophy (that is favorable for cardiac function) by changing the concentration of growth factors and their receptors. The aim of this study was to determine the effects of eight weeks of resistance training on activin receptor type II-B (ActRIIβ), as well as plasma levels of growth differentiation factor 11 (GDF11) and growth differentiation factor 8 (GDF8) in cardiac physiological hypertrophy in male Wistar rats. Methods: After the familiarization period, fourteen 3-month-old male Wistar rats were randomly divided into control and training groups (n= 7). Resistance training included 8 weeks and 5 sessions per week climbing from a 1-meter ladder. GDF11 and GDF8 of plasma were measured using enzyme-linked immunosorbent assay (ELISA) method, and ActRIIB of left ventricular myocardium was measured using immunohistochemistry (IHC) method. Data were analyzed using independent t test and Mann-Whitney U at the significance level of P < 0.050. Findings: There was a significant difference between the training and control groups in heart weight (P = 0.004), heart weight/body weight (P =0.045), GDF11 (P = 0.001), and GDF8/GDF11 (P = 0.015). There was not any significant differences between the training and control groups in ActRIIβ (P = 0.768) and GDF8 (P = 0.295) levels. Conclusion: According to the results of the present study, it seems that resistance training with favorable effects on growth factors is an important strategy in cardiac physiological hypertrophy.http://jims.mui.ac.ir/index.php/jims/article/view/10576Resistance trainingActivin receptor type II-BGrowth-differentiation factor 11Growth differentiation factor 8Cardiac hypertrophy |
| spellingShingle | Behnam Masoudian Akbar Azamian-Jazi Mohammad Faramarzi Ardeshir Talebi The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats مجله دانشکده پزشکی اصفهان Resistance training Activin receptor type II-B Growth-differentiation factor 11 Growth differentiation factor 8 Cardiac hypertrophy |
| title | The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats |
| title_full | The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats |
| title_fullStr | The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats |
| title_full_unstemmed | The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats |
| title_short | The Effect of Eight Weeks of Resistance Training on Activin Receptor type II-B and Plasma Levels of Growth Differentiation Factor 11 and 8 in Cardiac Physiological Hypertrophy in Male Wistar Rats |
| title_sort | effect of eight weeks of resistance training on activin receptor type ii b and plasma levels of growth differentiation factor 11 and 8 in cardiac physiological hypertrophy in male wistar rats |
| topic | Resistance training Activin receptor type II-B Growth-differentiation factor 11 Growth differentiation factor 8 Cardiac hypertrophy |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/10576 |
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