Deleterious effect of Usutu virus on human neural cells.
In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neona...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-09-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC5600396?pdf=render |
| _version_ | 1811265987432939520 |
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| author | Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin |
| author_facet | Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin |
| author_sort | Sara Salinas |
| collection | DOAJ |
| description | In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neonatal death and birth defects, as well as neurological symptoms. USUV pathogenesis remains largely unexplored, despite significant human and veterinary associated disorders. Circulation of USUV in Africa was documented more than 50 years ago, and it emerged in Europe two decades ago, causing massive bird mortality. More recently, USUV has been described to be associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting USUV as a potential health threat. The aim of this study was to evaluate the ability of USUV to infect neuronal cells. Our results indicate that USUV efficiently infects neurons, astrocytes, microglia and IPSc-derived human neuronal stem cells. When compared to ZIKV, USUV led to a higher infection rate, viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence. |
| first_indexed | 2024-04-12T20:33:59Z |
| format | Article |
| id | doaj.art-8507367cfdf9455fa3fbaf624bd0d5da |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T20:33:59Z |
| publishDate | 2017-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-8507367cfdf9455fa3fbaf624bd0d5da2022-12-22T03:17:39ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352017-09-01119e000591310.1371/journal.pntd.0005913Deleterious effect of Usutu virus on human neural cells.Sara SalinasOrianne ConstantCaroline DesmetzJonathan BarthelemyJean-Marc LemaitreOllivier MilhavetNicolas NagotVincent FoulongneFlorence E PerrinJuan-Carlos SaizSylvie LecollinetPhilippe Van de PerreYannick SimoninIn the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neonatal death and birth defects, as well as neurological symptoms. USUV pathogenesis remains largely unexplored, despite significant human and veterinary associated disorders. Circulation of USUV in Africa was documented more than 50 years ago, and it emerged in Europe two decades ago, causing massive bird mortality. More recently, USUV has been described to be associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting USUV as a potential health threat. The aim of this study was to evaluate the ability of USUV to infect neuronal cells. Our results indicate that USUV efficiently infects neurons, astrocytes, microglia and IPSc-derived human neuronal stem cells. When compared to ZIKV, USUV led to a higher infection rate, viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence.http://europepmc.org/articles/PMC5600396?pdf=render |
| spellingShingle | Sara Salinas Orianne Constant Caroline Desmetz Jonathan Barthelemy Jean-Marc Lemaitre Ollivier Milhavet Nicolas Nagot Vincent Foulongne Florence E Perrin Juan-Carlos Saiz Sylvie Lecollinet Philippe Van de Perre Yannick Simonin Deleterious effect of Usutu virus on human neural cells. PLoS Neglected Tropical Diseases |
| title | Deleterious effect of Usutu virus on human neural cells. |
| title_full | Deleterious effect of Usutu virus on human neural cells. |
| title_fullStr | Deleterious effect of Usutu virus on human neural cells. |
| title_full_unstemmed | Deleterious effect of Usutu virus on human neural cells. |
| title_short | Deleterious effect of Usutu virus on human neural cells. |
| title_sort | deleterious effect of usutu virus on human neural cells |
| url | http://europepmc.org/articles/PMC5600396?pdf=render |
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