Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving a dysregulated immune response which ultimately leads to multiple organ failure. Several immunological and cellular checkpoints are available as drug targets. However, the available chemosynthetic drugs such as non-steroid...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/4/1049 |
| _version_ | 1797569950279270400 |
|---|---|
| author | Acharya Balkrishna Pallavi Thakur Shivam Singh Swami Narsingh Chandra Dev Anurag Varshney |
| author_facet | Acharya Balkrishna Pallavi Thakur Shivam Singh Swami Narsingh Chandra Dev Anurag Varshney |
| author_sort | Acharya Balkrishna |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving a dysregulated immune response which ultimately leads to multiple organ failure. Several immunological and cellular checkpoints are available as drug targets. However, the available chemosynthetic drugs such as non-steroidal anti-inflammatory drugs and corticosteroids provide limited therapy with extreme toxicities. Moreover, the disease heterogeneity in SLE is very difficult to manage by a single drug component. Hence, it is imperative to utilize the holistic capabilities of natural plant products as immunomodulators and intracellular signaling regulators, thereby providing an auxiliary option of treatment. Additionally, the herbal drugs also serve as symptomatic relief providers, thereby serving as a prophylactic remedy in case of cerebrovascular, hepatic, nephropathological, hematological, cardiopulmonary, mucocutaneous and musculoskeletal manifestations of SLE. The present review attempts to showcase the current state of knowledge regarding the utility of plant-derived phyto-metabolites with their probable mechanistic roles in treating SLE, by means of targeting the signaling cascade, proinflammatory cytokine production and B–T cell co-stimulation. It is hoped that further preclinical and clinical studies will be embarked upon in order to understand the underlying therapeutic and mechanistic aspects of these medicinal herbs. |
| first_indexed | 2024-03-10T20:18:29Z |
| format | Article |
| id | doaj.art-85073ece61f94c729a233f67f230cceb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:18:29Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-85073ece61f94c729a233f67f230cceb2023-11-19T22:24:48ZengMDPI AGCells2073-44092020-04-0194104910.3390/cells9041049Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus ErythromatosusAcharya Balkrishna0Pallavi Thakur1Shivam Singh2Swami Narsingh Chandra Dev3Anurag Varshney4Drug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand 249 405, IndiaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand 249 405, IndiaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand 249 405, IndiaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand 249 405, IndiaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand 249 405, IndiaSystemic lupus erythematosus (SLE) is a complex autoimmune disorder involving a dysregulated immune response which ultimately leads to multiple organ failure. Several immunological and cellular checkpoints are available as drug targets. However, the available chemosynthetic drugs such as non-steroidal anti-inflammatory drugs and corticosteroids provide limited therapy with extreme toxicities. Moreover, the disease heterogeneity in SLE is very difficult to manage by a single drug component. Hence, it is imperative to utilize the holistic capabilities of natural plant products as immunomodulators and intracellular signaling regulators, thereby providing an auxiliary option of treatment. Additionally, the herbal drugs also serve as symptomatic relief providers, thereby serving as a prophylactic remedy in case of cerebrovascular, hepatic, nephropathological, hematological, cardiopulmonary, mucocutaneous and musculoskeletal manifestations of SLE. The present review attempts to showcase the current state of knowledge regarding the utility of plant-derived phyto-metabolites with their probable mechanistic roles in treating SLE, by means of targeting the signaling cascade, proinflammatory cytokine production and B–T cell co-stimulation. It is hoped that further preclinical and clinical studies will be embarked upon in order to understand the underlying therapeutic and mechanistic aspects of these medicinal herbs.https://www.mdpi.com/2073-4409/9/4/1049autoimmunityimmune regulationnatural plant productssystemic lupus erythematosusherbal medicines |
| spellingShingle | Acharya Balkrishna Pallavi Thakur Shivam Singh Swami Narsingh Chandra Dev Anurag Varshney Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus Cells autoimmunity immune regulation natural plant products systemic lupus erythematosus herbal medicines |
| title | Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus |
| title_full | Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus |
| title_fullStr | Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus |
| title_full_unstemmed | Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus |
| title_short | Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus |
| title_sort | mechanistic paradigms of natural plant metabolites as remedial candidates for systemic lupus erythromatosus |
| topic | autoimmunity immune regulation natural plant products systemic lupus erythematosus herbal medicines |
| url | https://www.mdpi.com/2073-4409/9/4/1049 |
| work_keys_str_mv | AT acharyabalkrishna mechanisticparadigmsofnaturalplantmetabolitesasremedialcandidatesforsystemiclupuserythromatosus AT pallavithakur mechanisticparadigmsofnaturalplantmetabolitesasremedialcandidatesforsystemiclupuserythromatosus AT shivamsingh mechanisticparadigmsofnaturalplantmetabolitesasremedialcandidatesforsystemiclupuserythromatosus AT swaminarsinghchandradev mechanisticparadigmsofnaturalplantmetabolitesasremedialcandidatesforsystemiclupuserythromatosus AT anuragvarshney mechanisticparadigmsofnaturalplantmetabolitesasremedialcandidatesforsystemiclupuserythromatosus |