Epigenetic Regulation: A Link between Inflammation and Carcinogenesis
Epigenetics encompasses a group of dynamic, reversible, and heritable modifications that occur within cells that are independent of gene mutations. These alterations are highly influenced by the environment, from the environment that surrounds the human being to the internal microenvironments locate...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/5/1221 |
| _version_ | 1797475484505735168 |
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| author | Bianca Vezzani Marianna Carinci Maurizio Previati Stefania Giacovazzi Mario Della Sala Roberta Gafà Giovanni Lanza Mariusz R. Wieckowski Paolo Pinton Carlotta Giorgi |
| author_facet | Bianca Vezzani Marianna Carinci Maurizio Previati Stefania Giacovazzi Mario Della Sala Roberta Gafà Giovanni Lanza Mariusz R. Wieckowski Paolo Pinton Carlotta Giorgi |
| author_sort | Bianca Vezzani |
| collection | DOAJ |
| description | Epigenetics encompasses a group of dynamic, reversible, and heritable modifications that occur within cells that are independent of gene mutations. These alterations are highly influenced by the environment, from the environment that surrounds the human being to the internal microenvironments located within tissues and cells. The ways that pigenetic modifications promote the initiation of the tumorigenic process have been widely demonstrated. Similarly, it is well known that carcinogenesis is supported and prompted by a strong proinflammatory environment. In this review, we introduce our report of a proinflammatory microenvironment that encircles the tumor core but can be responsible for the induction of epigenetic drift. At the same time, cancer cells can alter their epigenetic profile to generate a positive loop in the promotion of the inflammatory process. Therefore, an in-depth understanding of the epigenetic networks between the tumor microenvironment and cancer cells might highlight new targetable mechanisms that could prevent tumor progression. |
| first_indexed | 2024-03-09T20:45:47Z |
| format | Article |
| id | doaj.art-8509e093becc49238a0873d5432db484 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:45:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8509e093becc49238a0873d5432db4842023-11-23T22:47:40ZengMDPI AGCancers2072-66942022-02-01145122110.3390/cancers14051221Epigenetic Regulation: A Link between Inflammation and CarcinogenesisBianca Vezzani0Marianna Carinci1Maurizio Previati2Stefania Giacovazzi3Mario Della Sala4Roberta Gafà5Giovanni Lanza6Mariusz R. Wieckowski7Paolo Pinton8Carlotta Giorgi9Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, Section of Human Anatomy and Histology, University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, ItalyLaboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, 02-093 Warsaw, PolandDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyEpigenetics encompasses a group of dynamic, reversible, and heritable modifications that occur within cells that are independent of gene mutations. These alterations are highly influenced by the environment, from the environment that surrounds the human being to the internal microenvironments located within tissues and cells. The ways that pigenetic modifications promote the initiation of the tumorigenic process have been widely demonstrated. Similarly, it is well known that carcinogenesis is supported and prompted by a strong proinflammatory environment. In this review, we introduce our report of a proinflammatory microenvironment that encircles the tumor core but can be responsible for the induction of epigenetic drift. At the same time, cancer cells can alter their epigenetic profile to generate a positive loop in the promotion of the inflammatory process. Therefore, an in-depth understanding of the epigenetic networks between the tumor microenvironment and cancer cells might highlight new targetable mechanisms that could prevent tumor progression.https://www.mdpi.com/2072-6694/14/5/1221epigeneticscarcinogenesisinflammationtumor microenvironment |
| spellingShingle | Bianca Vezzani Marianna Carinci Maurizio Previati Stefania Giacovazzi Mario Della Sala Roberta Gafà Giovanni Lanza Mariusz R. Wieckowski Paolo Pinton Carlotta Giorgi Epigenetic Regulation: A Link between Inflammation and Carcinogenesis Cancers epigenetics carcinogenesis inflammation tumor microenvironment |
| title | Epigenetic Regulation: A Link between Inflammation and Carcinogenesis |
| title_full | Epigenetic Regulation: A Link between Inflammation and Carcinogenesis |
| title_fullStr | Epigenetic Regulation: A Link between Inflammation and Carcinogenesis |
| title_full_unstemmed | Epigenetic Regulation: A Link between Inflammation and Carcinogenesis |
| title_short | Epigenetic Regulation: A Link between Inflammation and Carcinogenesis |
| title_sort | epigenetic regulation a link between inflammation and carcinogenesis |
| topic | epigenetics carcinogenesis inflammation tumor microenvironment |
| url | https://www.mdpi.com/2072-6694/14/5/1221 |
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